The Why of YY1: Mechanisms of Transcriptional Regulation by Yin Yang 1.
The Why of YY1: Mechanisms of Transcriptional Regulation by Yin Yang 1.
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DOI：
10.3389/fcell.2020.592164
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发表时间：
2020
影响因子：
5.5
通讯作者：
Barakat TS
中科院分区：
文献类型：
--
作者：
Verheul TCJ;van Hijfte L;Perenthaler E;Barakat TS
Yin Yang 1（YY 1）是一种转录因子，在哺乳动物细胞中广泛表达。它调节转录激活和抑制，在一个看似上下文依赖的方式。YY1在中枢神经系统的发育中具有公认的作用，在中枢神经系统中，它参与神经发生和发育中大脑内稳态的维持。在神经发育和神经退行性疾病中，YY 1在中枢神经系统细胞过程中的关键作用得到进一步强调。在这篇简短的综述中，我们讨论了导致YY1的转录激活和抑制作用的各种机制，包括它作为传统转录因子的作用，它与辅因子和染色质修饰剂的相互作用，YY1在非编码基因组和3D染色质组织中的作用，以及相分离机制对YY1功能的可能影响。我们提供了这些过程如何参与正常发育以及改变如何导致各种疾病的例子。
First described in 1991, Yin Yang 1 (YY1) is a transcription factor that is ubiquitously expressed throughout mammalian cells. It regulates both transcriptional activation and repression, in a seemingly context-dependent manner. YY1 has a well-established role in the development of the central nervous system, where it is involved in neurogenesis and maintenance of homeostasis in the developing brain. In neurodevelopmental and neurodegenerative disease, the crucial role of YY1 in cellular processes in the central nervous system is further underscored. In this mini-review, we discuss the various mechanisms leading to the transcriptional activating and repressing roles of YY1, including its role as a traditional transcription factor, its interactions with cofactors and chromatin modifiers, the role of YY1 in the non-coding genome and 3D chromatin organization and the possible implications of the phase-separation mechanism on YY1 function. We provide examples on how these processes can be involved in normal development and how alterations can lead to various diseases.