Efficacy of an orally administered anti-diarrheal probiotic paste (Pro-Kolin Advanced) in dogs with acute diarrhea: A randomized, placebo-controlled, double-blinded clinical study
Efficacy of an orally administered anti-diarrheal probiotic paste (Pro-Kolin Advanced) in dogs with acute diarrhea: A randomized, placebo-controlled, double-blinded clinical study
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DOI：
10.1111/jvim.15481
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发表时间：
2019-05-01
影响因子：
2.6
通讯作者：
Muller, Annika T.
中科院分区：
文献类型：
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作者：
Nixon, Sophie L.;Rose, Lindsay;Muller, Annika T.
背景急性腹泻是犬常见的临床表现。特异性抗腹泻益生菌糊剂（ADPP）在治疗犬急性无并发症腹泻中的作用尚不清楚。假设与安慰剂相比，给予含有屎肠球菌4 b1707的ADPP将改善犬急性无并发症腹泻的临床结局。动物148只客户拥有的犬，以急性腹泻为主要临床体征。方法在英国和爱尔兰的14家初级保健兽医诊所进行双盲、安慰剂对照、随机、区组、多中心临床田间研究。结果ADPP在急性、无并发症腹泻犬中与安慰剂相比具有更好的临床结局。ADPP组的狗腹泻持续时间明显缩短（ADPP：中位数，32小时; 95%置信区间[CI]，2-118; n = 51;安慰剂：中位数，47小时; 95% CI，4-167; n = 58; P = .008），ADPP组腹泻消退速度是安慰剂组的1.60倍（比值，1.60; 95% CI，1.08-2.44; P = .02）。与安慰剂组相比，ADPP组中因未改善或恶化而需要额外医疗干预（AMI）的犬较少（分别为3.5%和14.8%），相对风险为0.88（P = 0.04; AMI，ADPP，3.5%，2/57只犬;安慰剂，14.8%，9/61只犬;相对风险，0.88; 95% CI，0.77-0.99）。结论和临床意义ADPP可加速犬急性腹泻的消退，减少AMI的需要量。
Background Acute diarrhea is a common clinical presentation of dogs. The effect of specific anti-diarrheal probiotic pastes (ADPPs) in the management of acute, uncomplicated diarrhea in dogs is unknown. Hypothesis Administration of an ADPP containing Enterococcus faecium 4b1707 will improve the clinical outcome of acute, uncomplicated diarrhea in dogs compared to placebo. Animals One hundred forty-eight client-owned dogs with acute diarrhea as the main clinical sign. Methods Double-blinded, placebo-controlled, randomized, blocked, multicenter clinical field study conducted at 14 primary care veterinary practices in the United Kingdom and Ireland. Results The ADPP was associated with better clinical outcome compared to placebo in dogs with acute, uncomplicated diarrhea. Dogs in the ADPP group had a significantly shorter duration of diarrhea (ADPP: median, 32 hours; 95% confidence interval [CI], 2-118; n = 51; Placebo: median, 47 hours; 95% CI, 4-167; n = 58; P = .008) and the rate of resolution of diarrhea was 1.60 times faster in the ADPP group than in the Placebo group (ratio, 1.60; 95% CI, 1.08-2.44; P = .02). Fewer dogs required additional medical intervention (AMI) for non-improvement or worsening in the ADPP group compared to the Placebo group (3.5% of dogs and 14.8% of dogs, respectively), with a relative risk of 0.88 (P = .04; AMI, ADPP, 3.5%, 2/57 dogs; Placebo, 14.8%, 9/61 dogs; relative risk, 0.88; 95% CI, 0.77-0.99). Conclusion and Clinical Importance The ADPP may accelerate resolution of acute diarrhea in dogs and decrease the requirement for AMI.