Diabetic neuropathy: clinical manifestations and current treatments.
Diabetic neuropathy: clinical manifestations and current treatments.
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DOI：
10.1016/s1474-4422(12)70065-0
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发表时间：
2012-06
期刊：
影响因子：
--
通讯作者：
Feldman EL
中科院分区：
文献类型：
--
作者：
Callaghan BC;Cheng HT;Stables CL;Smith AL;Feldman EL
糖尿病周围神经病变是一种普遍的致残性疾病。最常见的表现是远端对称性多发性神经病（DSP），但可能发生多种神经损伤模式。目前，唯一有效的治疗方法是血糖控制和疼痛管理。虽然葡萄糖控制显著降低了1型糖尿病患者神经病变的发展，但对2型糖尿病患者的影响可能要小得多。高水平的证据支持使用某些抗惊厥药和抗抑郁药治疗糖尿病周围神经病变的疼痛。然而，由于缺乏糖尿病DSP的疾病改善疗法，因此必须确定新的可改变的风险因素。有趣的是，越来越多的证据支持代谢综合征组分（包括糖尿病前期）与神经病变之间的关联。未来的研究需要进一步探索这种关系，并为这种常见疾病提供新的治疗方法。
Diabetic peripheral neuropathy is a prevalent, disabling condition. The most common manifestation is a distal symmetric polyneuropathy (DSP), but many patterns of nerve injury can occur. Currently, the only effective treatments are glucose control and pain management. While glucose control dramatically decreases the development of neuropathy in those with type 1 diabetes, the effect is likely much smaller in those with type 2 diabetes. High levels of evidence support the use of certain anticonvulsants and antidepressants for pain management in diabetic peripheral neuropathy. However, the lack of disease modifying therapies for diabetic DSP makes the identification of new modifiable risk factors essential. Intriguingly, growing evidence supports an association between metabolic syndrome components, including pre-diabetes, and neuropathy. Future studies are needed to further explore this relationship with implications for new treatments for this common disease.