GROWTH-HORMONE RELEASING-FACTOR FROM A HUMAN PANCREATIC TUMOR THAT CAUSED ACROMEGALY
GROWTH-HORMONE RELEASING-FACTOR FROM A HUMAN PANCREATIC TUMOR THAT CAUSED ACROMEGALY
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DOI：
10.1126/science.6812220
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发表时间：
1982-01-01
期刊：
影响因子：
56.9
通讯作者：
WEHRENBERG, WB
中科院分区：
文献类型：
--
作者：
GUILLEMIN, R;BRAZEAU, P;WEHRENBERG, WB
从引起肢端肥大症的人胰腺肿瘤中分离出具有生长激素释放活性的44个氨基酸的肽。肿瘤衍生肽的一级结构为H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH 2。合成的复制品在体外和体内具有完全的生物活性，特异性地刺激免疫反应性生长激素的分泌。该肿瘤衍生肽与下丘脑组织提取物中存在的尚未表征的生长激素释放因子在生物学活性上相同，在物理化学性质上相似。
A 44 amino acid peptide with growth hormone-releasing activity was isolated from a human tumor of the pancreas that had caused acromegaly. The primary structure of the tumor-derived peptide is H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2. The synthetic replicate has full biological activity in vitro and in vivo specifically to stimulate the secretion of immunoreactive growth hormone. The tumor-derived peptide is identical in biological activity and similar in physicochemical properties to the still uncharacterized growth hormone-releasing factor present in exracts of hypothalamic tissues.