Steady-state relationship between average glucose, HbA1c and RBC lifespan
Steady-state relationship between average glucose, HbA1c and RBC lifespan
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DOI：
10.1016/j.jtbi.2018.03.023
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发表时间：
2018-06-14
影响因子：
2
通讯作者：
Ishii, Shinya
中科院分区：
文献类型：
--
作者：
Kameyama, Masashi;Takeuchi, Sousuke;Ishii, Shinya
糖化血红蛋白（HbA1c）用于估算平均血糖。先前的研究表明平均血糖与HbA1c之间呈线性关系。我们利用近期提出的红细胞寿命的类伽马函数模型建立了一种新的理论关系。我们展示了平均血糖与HbA1c之间的关系，并将其近似为一个简单的双曲线函数：HbA1c = M(RBC)k(g)AG / (1 + (2/3)M(RBC)k(g)AG)，其反函数很容易得出。明显的线性关系是曲线关系的一种近似。双曲线函数将比线性方程提供更准确的近似。医生应牢记这种曲线关系，并意识到极高的HbA1c表明血糖水平加速升高。（C）2018爱思唯尔有限公司。保留所有权利。
HbA1c is used to estimate average glucose. Previous studies showed linear relationship between average glucose and HbA1c. We made a new theoretical relationship using recently proposed Gamma-like function model of erythrocyte lifespan. We showed the relationship between average glucose and HbA1c; we approximated it into a simple hyperbolic function: HbA1c = M(RBC)k(g)AG/(1 + (2/3)M(RBC)k(g)AG), whose inverse function is easily obtained. Apparent linear relationship is an approximation of the curved relationship. Hyperbolic function would provide a more accurate approximation than a linear equation. Physicians should keep in mind the curved relationship and be aware that extremely high HbA1c indicates acceleratingly high glucose level. (C) 2018 Elsevier Ltd. All rights reserved.