Apoptosis in systemic lupus erythematosus - Clinical implications
Apoptosis in systemic lupus erythematosus - Clinical implications
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DOI：
10.1016/s0889-857x(05)70136-8
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发表时间：
2000-05-01
影响因子：
2.3
通讯作者：
Rosen, A
中科院分区：
文献类型：
--
作者：
Andrade, F;Casciola-Rosen, L;Rosen, A
系统性红斑狼疮是一组病因不明的异质性和复杂的疾病。最近的研究表明，凋亡细胞死亡过程的异常可能通过改变抗原的产生和切割以及免疫调节的异常在这一系列疾病的启动和传播中发挥重要作用。聚集和浓度的自身抗原中和表面泡的凋亡细胞，在某些形式的凋亡性死亡的抗原结构的修改，并在人类与SLE和某些动物模型的凋亡细胞清除异常进行审查和合成成一个全面的模型系统性自身免疫。
SLE is a heterogeneous and complex group of disorders of uncertain cause. Recent studies have suggested that abnormalities in the apoptotic cell death process may play an important role in the initiation and propagation of this spectrum of disease by altering the generation and cleavage of antigens, and through abnormalities in immunoregulation. The clustering and concentration of autoantigens in and on the surface blebs of apoptotic cells, modifications of antigen structure during certain forms of apoptotic death, and abnormalities in apoptotic cell clearance in humans with SLE and in certain animal models are reviewed and synthesized into a comprehensive model of systemic autoimmunity.