Visualizing fitness landscapes.
Visualizing fitness landscapes.
复制标题
DOI：
10.1111/j.1558-5646.2011.01236.x
复制
发表时间：
2011-06
期刊：
影响因子：
--
通讯作者：
McCandlish DM
中科院分区：
文献类型：
--
作者：
McCandlish DM
Fitness landscapes are a classical concept for thinking about the relationship between genotype and fitness. However, because the space of genotypes is typically high-dimensional, the structure of fitness landscapes can be difficult to understand and the heuristic approach of thinking about fitness landscapes as low-dimensional, continuous surfaces may be misleading. Here I present a rigorous method for creating low-dimensional representations of fitness landscapes. The basic idea is to plot the genotypes in a manner that reflects the ease or difficulty of evolving from one genotype to another. Such a layout can be constructed using the eigenvectors of the transition matrix describing the evolution of a population on the fitness landscape when mutation is weak. In addition, the eigendecomposition of this transition matrix provides a new, high-level view of evolution on a fitness landscape. I demonstrate these techniques by visualizing the fitness landscape for selection for the amino acid serine and by visualizing a neutral network derived from the RNA secondary structure genotype-phenotype map.
登录
查看更多内容
影响因子：
1.8
作者：
HOFACKER, IL;FONTANA, W;SCHUSTER, P
通讯作者：
SCHUSTER, P
影响因子：
46.9
作者：
Berger, Michael F.;Philippakis, Anthony A.;Bulyk, Martha L.
通讯作者：
Bulyk, Martha L.
DOI：
10.1073/pnas.96.19.10689
发表时间：
1999-09-14
影响因子：
11.1
作者：
Bornberg-Bauer, E;Chan, HS
通讯作者：
Chan, HS
影响因子：
1.8
作者：
Gruner, W;Giegerich, R;Schuster, P
通讯作者：
Schuster, P
影响因子：
2.5
作者：
Calcott, Brett
通讯作者：
Calcott, Brett