Association analysis of toll-like receptor 4 polymorphisms in Japanese primary biliary cirrhosis
Association analysis of toll-like receptor 4 polymorphisms in Japanese primary biliary cirrhosis
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DOI：
10.1016/j.humimm.2012.10.022
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发表时间：
2013-02-01
期刊：
影响因子：
2.7
通讯作者：
Ota, Masao
中科院分区：
文献类型：
--
作者：
Morita, Susumu;Joshita, Satoru;Ota, Masao
原发性胆汁性肝硬化（PBC）以门静脉炎症和免疫介导的肝内胆管破坏为特征，常导致肝功能衰竭。toll样受体（TLR） 4识别革兰氏阴性菌的脂多糖。由于在PBC肝组织的胆管上皮细胞和门静脉周围肝细胞中发现TLR4表达，因此怀疑感染因子在PBC发病中起关键作用。为了评估TLR4 snp对该疾病发展的潜在贡献，我们使用TaqMan试验对261名PBC患者和359名对照者的TLR4中5个snp进行了基因分型。未发现与PBC易感性或进展有显著正相关。这些结果表明，TLR4多态性在日本PBC患者的发展中并不起突出作用。(C) 2012年美国组织相容性和免疫遗传学学会。Elsevier Inc.出版。版权所有。
Primary biliary cirrhosis (PBC) is characterized by portal inflammation and immune-mediated destruction of intrahepatic bile ducts that often result in liver failure. Toll-like receptor (TLR) 4 recognizes lipopolysaccharides of Gram-negative bacteria. Infectious agents have been suspected to play a crucial role in PBC pathogenesis since TLR4 expression was found in bile duct epithelial cells and periportal hepatocytes in liver tissues of PBC. To assess the potential contribution of TLR4 SNPs to the development of this disease, we genotyped five SNPs in TLR4 in 261 PBC patients and 359 controls using a TaqMan assay. No significant positive associations with either PBC susceptibility or progression were uncovered. These results indicate that TLR4 polymorphisms do not play a prominent role in the development of PBC in Japanese patients. (C) 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.