Cationic Peptidopolysaccharide with an Intrinsic AIE Effect for Combating Bacteria and Multicolor Imaging
Cationic Peptidopolysaccharide with an Intrinsic AIE Effect for Combating Bacteria and Multicolor Imaging
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具有内在 AIE 效应的阳离子肽多糖用于抗菌和多色成像
DOI：
10.1002/adhm.202000419
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发表时间：
2020-05-19
影响因子：
10
通讯作者：
Wang, Caiqi
中科院分区：
文献类型：
--
作者：
Dong, Zhenzhen;Wang, Yandong;Wang, Caiqi
采用简单的合成方法构建了一种集抗菌和检测功能于一体的抗菌聚合肽多糖（COS-AMP）。COS-AMP是模拟细菌细胞壁肽聚糖的结构，以具有固有聚集诱导发射（AIE）效应的壳寡糖为主链，在其氨基上接枝一个肽聚合物而构建的。基于COS-AMP的AIE效应和激发依赖性荧光，将其初步应用于细菌的荧光成像和定量。这种荧光成像有助于匹配荧光仪器的不同激发源，以实现直接的成像和检测。与细菌细胞壁组分的结构相似性有利于COS-AMP穿过细胞壁并破坏细菌结构，因此具有良好的广谱抗菌活性。此外，不需要芳香族荧光团，优良的生物相容性将使其具有广阔的应用前景。
An antibacterial polymer peptidopolysaccharide (COS-AMP) that integrates antibacterial and detection functions is constructed with a simple synthetic method. The COS-AMP is constructed by simulating the structure of peptidoglycan of the bacterial cell wall with chitooligosaccharide with intrinsic aggregation-induced emission (AIE) effect as the main chain, as well as a peptide polymer grafted onto its amino group. Based on the AIE effect and excitation-dependent fluorescence of COS-AMP, it is tentatively applied to multicolor imaging and quantification of bacteria. This multicolor imaging helps to match different excitation sources of fluorescent instrument for straightforward imaging and detection. The structural similarity with the bacterial cell wall component facilitates the passage of COS-AMP across the cell wall and destroys the bacterial structure, thus it has a good broad-spectrum antibacterial activity. In addition, aromatic fluorophores are not needed, and excellent biocompatibility will make it have broad application prospects.