Minicolumnar width: Comparison between supragranular and infragranular layers
Minicolumnar width: Comparison between supragranular and infragranular layers
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DOI：
10.1016/j.jneumeth.2009.07.011
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发表时间：
2009-10-30
影响因子：
3
通讯作者：
Trippe, Juan
中科院分区：
文献类型：
--
作者：
Casanova, Manuel F.;El-Baz, Ayman;Trippe, Juan
The minicolumn derives from the radial migration of neurons along glial scaffoldings during gestation. Investigators have presumed the minicolumn to be a single-cell wide structure based on their rectilinear migratory origin. The present study measures the width of minicolumnar cores in both supra- and infragranular layers. Postmortem tissue was obtained from 9 brain areas in 7 normative individuals. Examined tissues were celloidin embedded and Nissl stained. Digital images were denoised and then analyzed with a step-wise algorithm involving region growing and recursive line tracing. Significant differences were noted between the minicolumnar core widths of supra- and infra-granular layers. A review of the literature on corticogenesis provides some ideas as to how these laminar differences in minicolumnar core width are engendered. (C) 2009 Elsevier B.V. All rights reserved.
