Atherosclerosis: current understanding of mechanisms and future strategies in therapy.
Atherosclerosis: current understanding of mechanisms and future strategies in therapy.
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发表时间：
1993-04
影响因子：
0.9
通讯作者：
R. Ross
中科院分区：
文献类型：
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作者：
R. Ross
动脉粥样硬化的病变代表了一种保护性的、炎症性纤维增生性的反应，以对抗可能导致该疾病的不同因子。如果损伤持续足够长的时间，并且如果没有机会恢复动脉壁的正常结构，则病变可能发展到临床后遗症的程度。另一方面，如Brown等人、Kane等人和Blankenhorn等人所证明的，动脉粥样硬化的晚期病变可以显示为消退。对积极接受降脂药物（如HMGCoA还原酶抑制剂）治疗的患者进行的血管造影定量统计分析清楚地表明了这一点。因此，完全可以想象，这种慢性、过度、炎症和纤维增生反应可以逆转，只要有足够的机会使导致内皮和动脉壁损伤的因素得到控制和改变。
The lesions of atherosclerosis represent a protective, inflammatory-fibroproliferative response against the different agents that can cause the disease. If the injury continues chronically over a sufficiently long period of time, and if opportunity is not given for restitution of normal architecture in the artery wall, lesions may progress to a point at which clinical sequelae develop. On the other hand, as demonstrated by Brown et al, Kane et al, and Blankenhorn et al, the advanced lesions of atherosclerosis can be shown to regress. A quantitative, statistical analysis of angiograms in patients who are aggressively treated with lipid-lowering agents, such as HMGCoA reductase inhibitors has clearly shown this to be the case. Thus, it is entirely conceivable that this chronic, excessive, inflammatory, and fibroproliferative response can be reversed, given sufficient opportunity for the factors that have led to the endothelial and arterial wall injury causing these events to be taken into hand and modified.