Review: 5-HT1, 5-HT2, 5-HT3 and 5-HT7 Receptors and their Role in the Modulation of Pain Response in the Central Nervous System.
Review: 5-HT1, 5-HT2, 5-HT3 and 5-HT7 Receptors and their Role in the Modulation of Pain Response in the Central Nervous System.
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DOI：
10.2174/1570159x15666170911121027
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发表时间：
2018-01-30
影响因子：
5.3
通讯作者：
Alfaro-Rodríguez A
中科院分区：
文献类型：
--
作者：
Cortes-Altamirano JL;Olmos-Hernandez A;Jaime HB;Carrillo-Mora P;Bandala C;Reyes-Long S;Alfaro-Rodríguez A
本文综述了中枢5-羟色胺受体参与伤害性反应的机制。疼痛是身体的一种防御机制，引起生理、解剖、神经化学和心理变化，被定义为一种不愉快的感觉和情感体验，具有组织损伤的潜在风险，是全球医生预约的主要原因。由于不同类型的疼痛和用于治疗这种疾病的各种药物，这种症状的治疗已经产生了几种神经药理学研究。5-羟色胺[5-HydroxyTryptamine（5-HT）]是一种神经递质，有7个家族（5-HT 1 -5-HT 7）和大约15种受体亚型。5-羟色胺调节神经元的活动，然而，这种神经递质与许多生理过程，如心血管功能，胃运动，肾功能等。另一方面，一些研究报告，5-羟色胺调节伤害性反应，通过5-HT 1，5-HT 2，5-HT 3和5-HT 7受体在中枢神经系统（CNS）。在这篇综述中，对PubMed、ProQuest、EBSCO和科学引文索引进行了检索，以评估CNS中5-HT 1、5-HT 2、5-HT 3和5-HT 7受体对不同类型疼痛的调节作用。我们的结论是，5-HT 1，5-HT 2，5-HT 3和5-HT 7受体在中枢神经系统调节疼痛，但这取决于受体的分布，剂量的激动剂或拮抗剂，给药途径，疼痛类型和持续时间，以抑制，兴奋，甚至维持伤害性反应。
The aim of this review was to identify the mechanisms by which serotonin receptors involved at the central level are able to modulate the nociceptive response. Pain is a defense mechanism of the body that entails physio-logical, anatomical, neurochemical, and psychological changes, and is defined as an unpleasant sensory and emotional expe-rience with potential risk of tissue damage, comprising the leading cause of appointments with Physicians worldwide. Treatment for this symptom has generated several neuropharmacological lines of research, due to the different types of pain and the various drugs employed to treat this condition. Serotonin [5-HydroxyTryptamine (5-HT)] is a neurotransmitter with seven families (5-HT1–5-HT7) and approximately 15 receptor subtypes. Serotonin modulates neuronal activity; however, this neurotransmitter is related with a number of physiological processes, such as cardiovascular function, gastric motility, renal function, etc. On the other hand, several researches reported that serotonin modulates nociceptive response through 5-HT1, 5-HT2, 5-HT3, and 5-HT7 receptors in the Central Nervous System (CNS). In this review, a search was conducted on PubMed, ProQuest, EBSCO, and the Science Citation Index for studies evaluating the effects of 5-HT1, 5-HT2, 5-HT3, and 5-HT7 receptors in the CNS on the modulation of different types of pain. We concluded that 5-HT1, 5-HT2, 5-HT3, and 5-HT7 receptors in the CNS modulate the pain, but this depends on the distribution of the receptors, dose of agonists or antagonists, administration route, pain type and duration in order to inhibit, excite, or even maintain the nociceptive response.