Physical exercise and Parkinson's disease: influence on symptoms, disease course and prevention
Physical exercise and Parkinson's disease: influence on symptoms, disease course and prevention
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DOI：
10.1515/revneuro-2012-0087
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发表时间：
2013-04-01
影响因子：
4.1
通讯作者：
Massano, Joao
中科院分区：
文献类型：
--
作者：
Grazina, Rita;Massano, Joao
帕金森氏病(PD)是一种常见的致残神经退行性疾病，预计在未来几十年内，该疾病的患病率将在全球范围内上升。对症治疗仍然不令人满意，到目前为止，迫切需要的神经保护疗法还没有成功开发出来。体育锻炼(PE)与患神经退行性疾病的风险较低有关。对文献进行了检索，并对PE在PD中的作用进行了系统化和解释。已发表的数据表明：1)体育与患帕金森氏症的风险较低；2)体育已被证明可以改善疾病症状、活动度、平衡性、步态和生活质量(在这方面，步行训练、太极和探戈舞证明了最高水平的有效性)；以及3)体育对帕金森氏症的神经保护作用是可以预期的，尽管这只在动物研究中被提出。应鼓励对这一专题进行进一步研究。神经学家、运动医生和研究人员之间的多学科合作至关重要。
Parkinson's disease (PD) is a common, disabling, neurodegenerative condition, and the disease prevalence is expected to increase worldwide in the next few decades. Symptomatic therapy remains unsatisfactory, and greatly needed neuroprotective therapies have not been successfully developed so far. Physical exercise (PE) has been associated with a lower risk of developing a neurodegenerative disease. The literature has been searched, and results have been systematized and interpreted with regard to the effects of PE in PD. Published data show the following: 1) PE has been associated with a lower risk of developing PD; 2) PE has been shown to improve disease symptoms, mobility, balance, gait and quality of life (in this regard, walking training, tai-chi and tango dancing have demonstrated the highest level of evidence of efficacy); and 3) neuroprotective effects from PE could be expected in PD, although this has been suggested in animal studies only. Further research on this topic should be encouraged. Multidisciplinary cooperation between neurologists, sports physicians and researchers is paramount.