Macrophage-derived chemokine in malignant and tuberculous pleural effusions
Macrophage-derived chemokine in malignant and tuberculous pleural effusions
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DOI：
10.1111/j.1440-1843.2007.01059.x
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发表时间：
2007-07-01
期刊：
影响因子：
6.9
通讯作者：
Kawabe, Tsutomu
中科院分区：
文献类型：
--
作者：
Okamoto, Masakazu;Imaizumi, Kazuyoshi;Kawabe, Tsutomu
背景与目的：巨噬细胞源性趋化因子（MDC/CCL 22）是一种辅助性T细胞（Th）2型趋化因子。恶性胸腔积液和结核性胸腔积液都是典型的淋巴细胞性胸腔积液。恶性胸腔积液的Th 1反应比恶性胸腔积液更极化，恶性胸腔积液主要是Th 2。本研究的目的是比较结核性胸腔积液与恶性胸腔积液中MDC的水平，以帮助描绘MDC在Th 2与Th 1 effusions.Methods的作用：43例胸腔积液（32恶性，11结核性）进行了研究。结果：恶性胸腔积液中MDC的中位数浓度明显低于结核性胸腔积液（P < 0.005）。恶性积液中MDC的低浓度可能会降低其抗肿瘤活性，但MDC在恶性和结核性积液中的确切作用需要进一步研究。
Background and objectives: Macrophage-derived chemokine (MDC/CCL22) is recognized as a T-helper (Th) 2-type chemokine. Both malignant and tuberculous pleural effusions are typically lymphocytic pleural effusions. Tuberculous pleural effusions have a more polarized Th1 reaction than malignant effusions, which are predominantly Th2 in nature. The aim of this study was to compare the levels of MDC in malignant pleural effusions with those in tuberculous pleural effusions to help delineate the role of MDC in Th2 versus Th1 effusions.Methods: Forty-three patients with pleural effusions (32 malignant, 11 tuberculous) were studied. The concentration of MDC in the pleural effusion was measured by ELISA.Results: The median concentration of MDC was lower in malignant pleural effusions than in tuberculous pleural effusions (P < 0.005).Conclusions: MDC has been reported to both promote and suppress antitumour immunity. The low concentration of MDC in malignant effusions is likely to minimise its antitumour activity but the precise role of MDC in malignant and tuberculous effusions needs to be investigated further.