Magnetic Particle Imaging Tracers: State-of-the-Art and Future Directions
Magnetic Particle Imaging Tracers: State-of-the-Art and Future Directions
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DOI：
10.1021/acs.jpclett.5b00610
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发表时间：
2015-07-02
影响因子：
5.7
通讯作者：
Samia, Anna Cristina S.
中科院分区：
文献类型：
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作者：
Bauer, Lisa M.;Situ, Shu F.;Samia, Anna Cristina S.
磁粒子成像（MPI）是一种新兴的成像方式，在诊断成像和引导治疗中具有广阔的应用前景。MPI中的图像质量在很大程度上取决于其基于氧化铁纳米颗粒的示踪剂的性质。潜在的MPI示踪剂的选择目前是有限的，示踪剂响应的基本物理尚未完全理解。通过协调一致的理论和实验工作获得的MPI示踪剂的磁弛豫过程的深入了解，是至关重要的优化MPI示踪剂的发展。虽然定制示踪剂将导致图像质量的改善，定制弛豫也可以用于生物医学应用或更灵活的图像对比度，如最近的彩色MPI演示。
Magnetic particle imaging (MPI) is an emerging imaging modality with promising applications in diagnostic imaging and guided therapy. The image quality in MPI is strongly dependent on the nature of its iron oxide nanoparticle-based tracers. The selection of potential MPI tracers is currently limited, and the underlying physics of tracer response is not yet fully understood. An in-depth understanding of the magnetic relaxation processes that govern MPI tracers, gained through concerted theoretical and experimental work, is crucial to the development of optimized MPI tracers. Although tailored tracers will lead to improvements in image quality, tailored relaxation may also be exploited for biomedical applications or more flexible image contrast, as in the recent demonstration of color MPI.