A Light-Responsive Release Platform by Controlling the Wetting Behavior of Hydrophobic Surface
A Light-Responsive Release Platform by Controlling the Wetting Behavior of Hydrophobic Surface
复制标题
通过控制疏水表面润湿行为的光响应释放平台
DOI：
10.1021/nn405398d
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发表时间：
2014-01-01
期刊：
影响因子：
17.1
通讯作者：
Jiang, Lei
中科院分区：
文献类型：
--
作者：
Chen, Linfeng;Wang, Wenqian;Jiang, Lei
基于介孔二氧化硅(MS)纳米材料的控释体系由于其潜在的生物医学应用，在过去的几十年里引起了人们的极大关注。本文通过调节MS表面的润湿性，实现了一种基于MS纳米颗粒的光响应释放系统。在初始阶段，用螺吡喃和氟化硅烷的最佳比例(MS-FSP)修饰的MS表面被保护，不被水润湿，成功地抑制了模型货物分子荧光素二钠(FD)的释放。在365 nm紫外光照射下，螺吡喃的构象从“封闭”状态转变为“开放”状态，导致表面被润湿，导致FD从孔中释放出来。进一步的体外研究表明，该系统可以有效地控制抗癌药物喜树碱(CPT)在紫外光刺激下的释放，从而增强对EA.hy926细胞和HeLa细胞的细胞毒作用。这种由润湿性决定的智能释放平台可以由远程刺激触发，这可能在药物输送和癌症治疗方面的应用前景光明。
Controlled release system based on mesoporous silica (MS) nanomaterials has drawn great attention over the past decades due to its potential biomedical applications. Herein, a light responsive release system based on MS nanoparticles was achieved by adjusting the wetting of the MS surface. At the starting stage, the surface of MS modified with optimal ratio of spiropyran to fluorinated silane (MS-FSP) was protected from being wetted by water, successfully inhibiting the release of model cargo molecules, fluorescein disodium (FD). Upon irradiation with 365 nm UV light, the conformational conversion of spiropyran from a "closed" state to an "open" state caused the surface to be wetted, leading to the release of FD from the pores. The further in vitro studies demonstrated the system loaded with anticancer drug camptothecin (CPT) could be effectively controlled to release the drug by UV light stimuli to enhance cytotoxicity for EA.hy926 cells and He La cells. This wettability-determined smart release platform could be triggered by remote stimuli, which might hold promise in the applications of drug delivery and cancer therapy.