VOLUME ADJUSTMENT OF MECHANICS AND DIFFUSION IN INTERSTITIAL LUNG-DISEASE - LACK OF CLINICAL RELEVANCE
VOLUME ADJUSTMENT OF MECHANICS AND DIFFUSION IN INTERSTITIAL LUNG-DISEASE - LACK OF CLINICAL RELEVANCE
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DOI：
10.1378/chest.96.5.1036
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发表时间：
1989-11-01
期刊：
影响因子：
9.6
通讯作者：
GOLDRING, RM
中科院分区：
文献类型：
--
作者：
KANENGISER, LC;RAPOPORT, DM;GOLDRING, RM
在38例间质性肺疾病患者中检查了肺力学和弥散与肺容量的关系，以确定减少模式是否与疾病的严重程度有关，区分组织学特征或预测可逆性预后。在整个疾病严重程度范围内，观察到力学和阻力的正常体积相关值。在同一患者中，力学与肺容积的比值与弥散与肺容积的比值不相关。力学和扩散的体积关系未能区分纤维化或炎症/肉芽肿的病理优势。这些比值不能预测重复试验患者的可逆性。这些结果表明，在间质性肺病患者中，应谨慎看待力学和弥散的“体积调节”的意义;这些参数似乎无助于病理生理学评估或与间质性肺病的临床谱相关。
Relationships of lung mechanics and diffusion to lung volume were examined in 38 patients with interstitial lung disease to determine whether patterns of reduction relate to severity of disease, distinguish histologic characteristics or predict prognosis for reversibility. Normal volume-related values for both mechanics and duffusion were seen throughout the range of severity of disease. The ratio of mechanics to lung volume did not correlate with the ratio of diffusion to lung volume in the same patient. Volume relationships of mechanics and diffusion failed to distinguish pathologic predominance of fibrosis or inflammation/granulomas. These ratios failed to predict reversibility in patients who had repeated tests. These results suggest that in patients with interstitial lung disease the significance of "volume-adjustment" of mechanics and diffusion should be viewed with caution; these parameters do not appear to contribute to the assessement of pathophysiology or correlate with clinical spectrum of interstitial lung diseases.