The ubiquitous gp63-like metalloprotease from lower trypanosomatids: in the search for a function.
The ubiquitous gp63-like metalloprotease from lower trypanosomatids: in the search for a function.
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来自低等锥体虫的普遍存在的类 gp63 金属蛋白酶：正在寻找功能。
DOI：
10.1590/s0001-37652006000400006
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发表时间：
2006
影响因子：
1.3
通讯作者：
C. M. d'Avila
中科院分区：
文献类型：
--
作者：
A. L. Santos;M. Branquinha;C. M. d'Avila
植物和昆虫锥虫构成了低级锥虫，由于它们很容易在无菌条件下培养，因此被常规用作生化和分子研究的实验室模型，并且它们含有经典的人类锥虫病原体的毒力因子的同系物。在利什曼原虫致病的分子因素中。在毒力和致病方面，利什曼原虫的主要表面蛋白，又称MSP、PSP、利什曼溶血素、EC3.4.24.36和gp63，是利什曼原虫最丰富的表面蛋白。利什曼原虫gp63的多种功能已被描述。当超环前鞭毛体在哺乳动物宿主内时。然而，人们对这种分子在无脊椎动物载体中执行的功能知之甚少。有趣的是，gp63主要表达在利什曼原虫的昆虫阶段，以及迄今所研究的所有昆虫和植物锥虫中。在低级锥虫中发现的gp63同源物似乎在营养以及与昆虫上皮细胞的相互作用中发挥着重要作用。在过去的十年里，人们对蛋白水解酶在脊椎动物宿主中的作用进行了很好的评价，因此我们重点介绍了我们对低等锥虫中gp63类蛋白的生物化学和细胞生物学的理解的最新进展。
Plant and insect trypanosomatids constitute the "lower trypanosomatids", which have been used routinely as laboratory models for biochemical and molecular studies because they are easily cultured under axenic conditions, and they contain homologues of virulence factors from the classic human trypanosomatid pathogens. Among the molecular factors that contribute to Leishmania spp. virulence and pathogenesis, the major surface protease, alternatively called MSP, PSP, leishmanolysin, EC 3.4.24.36 and gp63, is the most abundant surface protein of Leishmania promastigotes. A myriad of functions have been described for the gp63 from Leishmania spp. when the metacyclic promastigote is inside the mammalian host. However, less is known about the functions performed by this molecule in the invertebrate vector. Intriguingly, gp63 is predominantly expressed in the insect stage of Leishmania, and in all insect and plant trypanosomatids examined so far. The gp63 homologues found in lower trypanosomatids seem to play essential roles in the nutrition as well as in the interaction with the insect epithelial cells. Since excellent reviews were produced in the last decade regarding the roles played by proteases in the vertebrate hosts, we focused in the recent developments in our understanding of the biochemistry and cell biology of gp63-like proteins in lower trypanosomatids.
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墨西哥利什曼原虫表面蛋白酶结构不同的基因受到发育调控。
影响因子：
1.5
作者：
Medina-Acosta,E;Karess,RE;Russell,DG
通讯作者：
Russell,DG
Crithidia fasciculata 含有转录的利什曼原虫表面蛋白酶 (gp63) 基因同源物。
影响因子：
1.5
作者：
Inverso,JA;Medina-Acosta,E;O'Connor,J;Russell,DG;Cross,GA
通讯作者：
Cross,GA
利什曼原虫表面蛋白酶 gp63 在补体固定、细胞粘附和对补体介导的裂解的抵抗中的作用。
DOI：
--
发表时间：
1995
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Brittingham,A;Morrison,CJ;McMaster,WR;McGwire,BS;Chang,KP;Mosser,DM
通讯作者：
Mosser,DM
影响因子：
1.5
作者：
Joshi, PB;Kelly, BL;McMaster, WR
通讯作者：
McMaster, WR