Threshold-like pattern of neuronal activation in the hypothalamus during treadmill running: Establishment of a minimum running stress (MRS) rat model
Threshold-like pattern of neuronal activation in the hypothalamus during treadmill running: Establishment of a minimum running stress (MRS) rat model
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DOI：
10.1016/j.neures.2007.04.004
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发表时间：
2007-08-01
影响因子：
2.9
通讯作者：
Saito, Tsuyoshi
中科院分区：
文献类型：
--
作者：
Soya, Hideaki;Mukai, Akira;Saito, Tsuyoshi
尽管有迹象表明跑步时下丘脑-垂体-肾上腺（HPA）轴被激活，但尚未有关于运动强度与下丘脑区域特异性神经活动之间关系的研究。为了解决这个问题，大鼠进行了30分钟的跑步，无论是在中速（超低速，25米分钟-(1)）或低速（亚低速，15米分钟（-1）），并计数c-Fos-(+)细胞，并与对照大鼠进行比较。血糖和乳酸水平显著升高，血浆ACTH和渗透压水平在超lt运行期间被观察到。只有lt上运动显著增加了下丘脑各区域的c-Fos诱导，即内侧视前区（MPO）、脑室周围核（Pe）、视交叉上核（SCN）、视上核（SON）、室旁核的细胞旁分裂（pPVN）、下丘脑前区（AH）、弓形核（ARC）和下丘脑后核（PH）。然而，亚低温对c-Fos积累没有影响。这表明下丘脑对跑步的反应是一种独特的阈值样模式，与之前报道的延髓的速度依赖模式不同[Ohiwa等人，2006a,b]。此外，这些结果显示了轻度运动的生理学基础，有助于建立我们的最小跑步压力（MRS）大鼠模型，或最小化下丘脑轴激活的跑步条件。(c) 2007爱思唯尔爱尔兰有限公司和日本神经科学学会。版权所有。
Despite the indication that the hypothalamo-pituitary-adrenal (HPA) axis is activated during treadmill running, there have not been any studies focusing on the relationship between exercise intensity and region-specific neural activities in hypothalamus. To address this, rats were subjected to 30 min of running, either at middle (supra-LT, 25 m min-(1)) or low speeds (sub-LT, 15 m min(-1)), and c-Fos-(+) cells were counted and compared with control rats. Significant increases in blood glucose and lactate levels, and plasma ACTH and osmolality levels were observed during supra-LT running. Only supra-LT running significantly increased c-Fos induction in various hypothalamic regions, namely, the medial preoptic area (MPO), periventricular nucleus (Pe), suprachiasmatic nucleus (SCN), supraoptic nucleus (SON), parvocellular division of the paraventricular nucleus (pPVN), anterior hypothalamic area (AH), arcuate nucleus (ARC) and posterior hypothalamic nucleus (PH). However, sub-LT caused no effect on c-Fos accumulation. This indicates that the hypothalamus responds uniquely to running in a threshold-like pattern distinct from the speeddependent pattern previously reported for the medulla oblongata [Ohiwa et al., 2006a,b]. In addition, these results showed a physiologic basis for mild exercise useful for establishing our minimum running stress (MRS) rat model, or the running conditions that minimize the activation of the HPA axis. (c) 2007 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.