ELECTRON-MICROSCOPIC ANALYSIS OF THE BONE TITANIUM INTERFACE
ELECTRON-MICROSCOPIC ANALYSIS OF THE BONE TITANIUM INTERFACE
复制标题
DOI：
10.3109/17453678308992868
复制
发表时间：
1983-01-01
期刊：
影响因子：
--
通讯作者：
LUNDSTROM, I
中科院分区：
文献类型：
--
作者：
LINDER, L;ALBREKTSSON, T;LUNDSTROM, I
将10枚聚碳酸酯制成的圆柱形种植体，覆盖120~250 nm厚的纯Tl层，植入5只兔的每只胫骨干骺端。观察时间为12wk。植入物周围是成熟的活骨。在骨和种植体之间的任何点上都没有软组织介入。在透射电子显微镜下，钛表面覆盖着一层20 nm厚的蛋白多糖，显示出基质的特征，并将胶原从种植体表面分离出来。界面处的单元同样由这样的层与钛隔开。在基质层中观察到羟基磷灰石晶体，有时似乎与钛直接接触。种植体表面100~500 nm处可见正常矿化。虽然这项研究的目的是定义界面解剖学，但它也表明宏观上光滑的钛表面可以很容易地愈合成骨，而不需要软组织包膜。这可能对永久固定植入物的材料选择和设计有帮助。
Ten cylindrical implants, made of polycarbonate and covered with a 120- to 250-nm-thick layer of pure TL, were implanted into each tibial metaphysis of 5 rabbits. Observation time was 12 wk. The implants were surrounded by mature, living bone. No soft tissue intervened between bone and implant at any point. With transmission electron microscopy the Ti was bordered by a 20-nm-thick layer of proteoglycans, showing the characteristics of ground substance, and separating the collagen from the implant surface. Cells at the interface were likewise separated from the Ti by such a layer. Hydroxyapatite crystals were observed within the ground substance layer, occasionally seemingly in direct contact with the Ti. Normal mineralization was present 100-500 nm from the implant surface. While this study aims at defining interface anatomy, it also shows that macroscopically smooth-surfaced Ti can readily heal into bone without a soft tissue envelope. This could be of help for materials'' choice and design of permanently fixed implants.