Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?
Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?
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DOI：
10.1038/nri2474
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发表时间：
2009-02-01
影响因子：
100.3
通讯作者：
Hamann, Alf
中科院分区：
文献类型：
--
作者：
Huehn, Jochen;Polansky, Julia K.;Hamann, Alf
调节性T（T - Reg）细胞是一种独特的T细胞谱系，在免疫耐受中起关键作用。几年前，叉头框P3（FOXP3）被确定为负责决定这些细胞发育和功能的转录因子。然而，参与FOXP3基因调控的潜在机制仍不清楚，因此妨碍了对T - Reg细胞的准确识别和操作。在这篇进展文章中，我们总结了在理解FOXP3表达如何被控制方面的最新进展，并强调了表明FOXP3基因座的表观遗传调控有助于其作为谱系特异性因子的作用的证据。
Regulatory T (T-Reg) cells constitute a unique T-cell lineage that has a crucial role in immunological tolerance. Several years ago, forkhead box P3 (FOXP3) was identified as the transcription factor that was responsible for determining the development and function of these cells. However, the underlying mechanisms that are involved in the regulation of the FOXP3 gene remain unclear and therefore preclude accurate identification and manipulation of T-Reg cells. In this Progress article, we summarize recent advances in understanding how FOXP3 expression is controlled and highlight evidence suggesting that epigenetic regulation of the FOXP3 locus contributes to its role as a lineage-specification factor.