(68)Ga-P15-041, A Novel Bone Imaging Agent for Diagnosis of Bone Metastases.
(68)Ga-P15-041, A Novel Bone Imaging Agent for Diagnosis of Bone Metastases.
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68Ga-P15-041，一种用于诊断骨转移的新型骨显像剂
DOI：
10.3389/fonc.2021.766851
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发表时间：
2021
影响因子：
4.7
通讯作者：
Li N
中科院分区：
文献类型：
--
作者：
Guo R;Meng X;Wang F;Yu J;Xie Q;Zhao W;Zhu L;Kung HF;Yang Z;Li N
68 Ga-P15 -041（68 Ga-HBED-CC-BP）是一种新型骨导向PET放射性示踪剂，可通过使用简单的试剂盒配方和内部68 Ga/68 Ge发生器轻松制备。本研究的目的是评估68 Ga-P15 -041用于临床PET/CT成像的潜在人体应用，并比较其与99 mTc-MDP全身骨显像（WBBS）检测不同癌症骨转移的有效性。仅使用68 Ga-P15 -041 PET/CT扫描，在5名组织病理学证实的癌症患者（3名男性，2名女性）中进行了使用Patlak分析和参数图的初始动力学研究。另一组51名组织病理学证实的癌症患者（22名男性，29名女性）在一周内依次接受了99 mTc-MDP WBBS和68 Ga-P15 -041 PET/CT扫描。以病理学检查或随访CT或MRI扫描为金标准，比较两种方法对骨转移瘤的诊断效能和受试者工作特征曲线（ROC）（p <0.05，有统计学意义）。51例患者进行了成像，并确定了174个骨转移部位。68 Ga-P15 -041 PET/CT和99 mTc-MDP WBBS分别检测到162个和81个转移灶。68 Ga-P15 -041 PET/CT和99 mTc-MDP WBBS诊断乳腺癌的敏感性、特异性、阳性预测值、阴性预测值和准确性分别为93.1%vs81.8%，89.8%vs90.7%，77.5%vs69.2%，97.2%vs93.4%，90.7%vs88.4%。结果表明，转移瘤的SUVmax均值为15.1 ± 6.9，明显高于良性病变的5.6 ± 1.3（P <0.001）。以SUVmax = 7.6作为PET/CT的临界值，可以预测转移的发生（AUC = 0.976; P <0.001; 95%CI：0.946-0.999）。然而，这是不可能区分成骨细胞骨转移和溶骨性骨病变。基于Patlak分析的参数图提供了出色的图像和非常有价值的定量信息。 68 Ga-P15 -041 PET/CT可在数分钟内提供快速骨扫描和高对比度图像，在检测骨转移方面上级当前选择的方法。因此，68 Ga-P15 -041 PET/CT可以成为一种有价值的常规核医学检查方法，为癌症患者骨转移的检测提供良好的图像。68 Ga-P15 -041可能成为一个有价值的补充，扩大收集68 Ga为基础的常规核医学程序，其中18F氟化物目前是不可用的。
68Ga-P15-041 (68Ga-HBED-CC-BP) is a novel bone-seeking PET radiotracer, which can be readily prepared by using a simple kit formulation and an in-house 68Ga/68Ge generator. The aim of this study is to assess the potential human application of 68Ga-P15-041 for clinical PET/CT imaging and to compare its efficacy to detect bone metastases of different cancers with 99mTc-MDP whole-body bone scintigraphy (WBBS). Initial kinetic study using Patlak analysis and parametric maps were performed in five histopathologically proven cancer patients (three males, two females) using 68Ga-P15-041 PET/CT scan only. Another group of 51 histopathologically proven cancer patients (22 males, 29 females) underwent both 99mTc-MDP WBBS and 68Ga-P15-041 PET/CT scans within a week, sequentially. Using either pathology examination or follow-up CT or MRI scans as the gold standard, the diagnostic efficacy and receiver operating characteristic curve (ROC) of the two methods in identifying bone metastases were compared (p <0.05, statistically significant). Fifty-one patients were imaged, and 174 bone metastatic sites were identified. 68Ga-P15-041 PET/CT and 99mTc-MDP WBBS detected 162 and 81 metastases, respectively. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 68Ga-P15-041 PET/CT and 99mTc-MDP WBBS were 93.1% vs 81.8%, 89.8% vs 90.7%, 77.5% vs 69.2%, 97.2% vs 93.4% and 90.7% vs 88.4%, respectively. Our results showed that the mean of SUVmax was significantly higher in metastases than that in benign lesions, 15.1 ± 6.9 vs. 5.6 ± 1.3 (P <0.001). Using SUVmax = 7.6 as the cut-off value by PET/CT, it was possible to predict the occurrence of metastases (AUC = 0.976; P <0.001; 95% CI: 0.946–0.999). However, it was impossible to distinguish osteoblastic bone metastases from osteolytic bone lesions. Parametric maps based on Patlak analysis provided excellent images and highly valuable quantitative information. 68Ga-P15-041 PET/CT, offering a rapid bone scan and high contrast images in minutes, is superior to the current method of choice in detecting bone metastases. It is reasonable to suggest that 68Ga-P15-041 PET/CT could become a valuable routine nuclear medicine procedure in providing excellent images for detecting bone metastases in cancer patients. 68Ga-P15-041 could become a valuable addition expanding the collection of 68Ga-based routine nuclear medicine procedures where 18F fluoride is not currently available.
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影响因子：
1.6
作者：
Hong, Haiyan;Ploessl, Karl;Kung, Hank F.
通讯作者：
Kung, Hank F.
影响因子：
4.6
作者：
Meisenheimer, Michael;Kuerpig, Stefan;Eppard, Elisabeth
通讯作者：
Eppard, Elisabeth
影响因子：
9.3
作者：
Minamimoto, Ryogo;Loening, Andreas;Iagaru, Andrei
通讯作者：
Iagaru, Andrei
影响因子：
3.8
作者：
Hernandez RK;Wade SW;Reich A;Pirolli M;Liede A;Lyman GH
通讯作者：
Lyman GH
影响因子：
10.6
作者：
Chakraborty, Dhritiman;Bhattacharya, Anish;Mittal, Bhagwant Rai
通讯作者：
Mittal, Bhagwant Rai