Retention of habituation of vestibulo-ocular reflex and sensation of rotation in humans
Retention of habituation of vestibulo-ocular reflex and sensation of rotation in humans
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DOI：
10.1007/s00221-008-1471-0
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发表时间：
2008-09-01
影响因子：
2
通讯作者：
Courjon, Jean-Hubert
中科院分区：
文献类型：
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作者：
Clement, Gilles;Tilikete, Caroline;Courjon, Jean-Hubert
在人类中，前庭眼反射（VOR）通过重复的热量或旋转刺激的习惯化已经得到了很好的证明。然而，很少有人注意到习惯化对自我旋转感觉的影响，对前庭习惯化的保持时间也知之甚少。为了研究这些特征，受试者暴露于偏航角速度阶跃的10个会话，其中椅子交替地在CW和CCW方向上旋转（双向协议）或总是在同一方向上旋转（单向协议），即，CW或CCW。在习惯化方案结束后长达8个月的时间内研究了由两种方案诱导的VOR习惯化和旋转感觉的保留。在两种方案中，VOR峰值慢相速度和时间常数在整个过程中均呈进行性下降。然后这些参数遵循指数恢复，时间常数约为1个月。旋转感觉的持续时间也习惯于在重复的角速度步骤，但它是较短的两个方向的刺激，包括后的单向协议。正弦VOR增益不受前庭对速度阶跃的习惯性影响，但正弦VOR相位在0.02和0.04 Hz时显示相位超前增加，其也在约1个月内恢复到基线值。我们的结论是前庭习惯化是一个长期的现象。这些结果可能有助于设计和调度方案的药物研究，使用交叉设计，平衡障碍患者的康复，以及间歇性人工重力在空间任务中的应用。
In humans, habituation of vestibulo-ocular reflex (VOR) by repeated caloric or rotational stimulation has been well documented. However, less attention has been directed to the effect of habituation on the sensation of self-rotation and little is known about the retention duration of vestibular habituation. To investigate these characteristics, subjects were exposed to ten sessions of angular velocity steps in yaw, with a chair rotating either alternatively in both CW and CCW directions (bidirectional protocol) or always in the same direction (unidirectional protocol), i.e., CW or CCW. The retention of habituation of VOR and sensation of rotation induced by both protocols was studied for a period up to 8 months following the end of the habituation protocols. There was a progressive decline in the VOR peak slow phase velocity and time constant throughout the sessions during both protocols. These parameters then followed an exponential recovery with a time constant of about 1 month. The duration of the sensation of rotation also habituated during repeated angular velocity steps, but it was shorter for both directions of stimulation, including after the unidirectional protocol. Sinusoidal VOR gain was not affected by vestibular habituation to velocity steps, but sinusoidal VOR phase showed an increase in phase lead at 0.02 and 0.04 Hz, which also returned to baseline values within about 1 month. We conclude that vestibular habituation is a long-lasting phenomenon. These results may be helpful for designing and scheduling the protocols for drug studies using crossover design, rehabilitation of balance disorder patients, and for the application of intermittent artificial gravity during space missions.