Epidemiology of sarcopenia among the elderly in New Mexico
Epidemiology of sarcopenia among the elderly in New Mexico
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DOI：
10.1093/oxfordjournals.aje.a009520
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发表时间：
1998-04-15
影响因子：
5
通讯作者：
Lindeman, RD
中科院分区：
文献类型：
--
作者：
Baumgartner, RN;Koehler, KM;Lindeman, RD
肌肉质量随着年龄的增长而减少，导致老年人的“肌肉减少症”或相对肌肉质量低。肌少症被认为与代谢、生理和功能障碍和残疾有关。缺乏估计老年人群中肌肉减少症患病率及其相关风险的方法。对居住在新墨西哥州的883名西班牙裔和非西班牙裔老年白人男性和女性的人口调查数据（新墨西哥州老年人健康调查，1993-1995年）进行了分析，以制定一种估计肌肉减少症患病率的方法。从参与者的随机子样本（n = 199）中开发了预测阑尾骨骼肌质量的人体测量方程，并将其扩展到总样本。骨骼肌减少症定义为阑尾骨骼肌质量(kg)/身高(2)（m(2)）低于年轻参照组平均值两个标准差。70岁以下人群的患病率从13-24%上升到80岁以上人群的50%，西班牙裔白人的患病率略高于非西班牙裔白人。骨骼肌减少症与男性和女性自我报告的身体残疾显著相关，与种族、年龄、发病率、肥胖、收入和健康行为无关。这项研究提供了一些由肌肉减少症引起的公共卫生问题程度的初步估计。
Muscle mass decreases with age, leading to "sarcopenia," or low relative muscle mass, in elderly people. Sarcopenia is believed to be associated with metabolic, physiologic, and functional impairments and disability. Methods of estimating the prevalence of sarcopenia and its associated risks in elderly populations are lacking. Data from a population-based survey of 883 elderly Hispanic and non-Hispanic white men and women living in New Mexico (the New Mexico Elder Health Survey, 1993-1995) were analyzed to develop a method for estimating the prevalence of sarcopenia. An anthropometric equation for predicting appendicular skeletal muscle mass was developed from a random subsample (n = 199) of participants and was extended to the total sample. Sarcopenia was defined as appendicular skeletal muscle mass (kg)/height(2) (m(2)) being less than two standard deviations below the mean of a young reference group. Prevalences increased from 13-24% in persons under 70 years of age to >50% in persons over 80 years of age, and were slightly greater in Hispanics than in non-Hispanic whites. Sarcopenia was significantly associated with self-reported physical disability in both men and women, independent of ethnicity, age, morbidity, obesity, income, and health behaviors. This study provides some of the first estimates of the extent of the public health problem posed by sarcopenia.