Compilation of gas chromatographic retention indices of 163 metabolically important organic acids, and their use in detection of patients with organic acidurias.
Compilation of gas chromatographic retention indices of 163 metabolically important organic acids, and their use in detection of patients with organic acidurias.
复制标题
163 种代谢重要有机酸的气相色谱保留指数汇编，及其在检测有机酸尿症患者中的应用。
DOI：
10.1016/s0021-9673(00)81990-1
复制
发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Hine,DG
中科院分区：
文献类型：
--
作者：
Tanaka,K;Hine,DG
气相色谱保留指数已被编译为163代谢重要的化合物（主要是有机酸）的形式的亚甲基单位，作为三甲基甲硅烷基衍生物，在10%OV-1和10%OV-17柱。通过检测这些代谢物可以诊断的代谢性疾病的综合参考文献被交叉索引，以便于使用亚甲基单元list.The气相色谱法，它利用乙酸乙酯和三甲基硅烷化提取尿液，进行了描述。还描述了改进的方法，一种用于中性化合物，一种用于高极性有机酸，这两种方法都利用适当的离子交换和冻干。这些方法的实际应用和使用的亚甲基单位列表中的11例各种代谢紊乱的诊断也显示。
Gas chromatographic retention indices have been compiled for 163 metabolically important compounds (mostly organic acids) in the form of methylene units, as trimethylsilyl derivatives, on 10% OV-1 and 10% OV-17 columns. Comprehensive references on metabolic diseases that can be diagnosed by detection of these metabolites are cross-indexed to facilitate the use of the methylene-unit list.The gas chromatographic method, which utilizes extraction of urine with ethyl acetate and trimethylsilylations, is described. Modified methods, one for neutral compounds and one for highly polar organic acids, both of which utilize appropriate ion exchange and lyophilization, are also described. Practical applications of these methods and the use of the methylene-unit list in the diagnosis of eleven patients with various metabolic disorders are also shown.