Are pediatric and adult-onset cyclic vomiting syndrome (CVS) biologically different conditions? Relationship of adult-onset CVS with the migraine and pediatric CVS-associated common mtDNA polymorphisms 16519T and 3010A
Are pediatric and adult-onset cyclic vomiting syndrome (CVS) biologically different conditions? Relationship of adult-onset CVS with the migraine and pediatric CVS-associated common mtDNA polymorphisms 16519T and 3010A
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DOI：
10.1111/j.1365-2982.2009.01305.x
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发表时间：
2009-09-01
影响因子：
3.5
通讯作者：
Mccallum, R.
中科院分区：
文献类型：
--
作者：
Boles, R. G.;Zaki, E. A.;Mccallum, R.
小儿周期性呕吐综合征（CVS）与偏头痛和其他功能性疾病的高患病率相关，并与两个成人偏头痛相关的线粒体DNA（mtDNA）多态性：16519 T和3010 A。这些潜在的关联尚未在成人CVS中进行研究。本研究的目的是确定16519 T和3010 A mtDNA多态性和其他功能障碍在成年CVS患者中的患病率。从符合罗马III标准的堪萨斯大学招募的CVS成人和一个人口对照组完成了一项自我报告的调查，其中包括与几种功能障碍的诊断标准有关的问题。从血液或唾液中分离DNA，并通过标准方法进行基因分型。与对照组相比，成年CVS受试者具有与其他几种功能障碍一致的明显更多的症状。16519 T存在于22/31例（71%）儿童发作（< 12岁）和9/31例（29%）成人发作（18岁以上）CVS病例中（P = 0.01），对照组为27%。在携带16519 T的受试者中，3010 A存在于30%的儿童发作型CVS中，而成人发作型CVS为0%（P = 0.05），对照组为2%。得出的结论是：（i）与儿科CVS不同，成人CVS与16519 T和3010 A mtDNA多态性无关，表明一定程度的遗传差异;（ii）与儿科环境相似，成人CVS与大量共病功能障碍相关。
P>Pediatric cyclic vomiting syndrome (CVS) is associated with a high prevalence of co-morbid migraine and other functional disorders, and with two adult migraine-associated mitochondrial DNA (mtDNA) polymorphisms: 16519T and 3010A. These potential associations have not been studied in adult CVS. The objective of this study is to determine the prevalence of 16519T and 3010A mtDNA polymorphisms and other functional disorders in adult CVS patients. Adults with CVS recruited from the University of Kansas meeting Rome III criteria and a population control group completed a self-reported survey that included questions relating to the diagnostic criteria for several functional disorders. DNA was isolated from blood or saliva and genotyping was performed by standard methodologies. Adult CVS subjects, compared to controls, had significantly more symptoms consistent with several other functional disorders. 16519T was present in 22/31 cases (71%) of child-onset (< 12 years) and 9/31 (29%) cases of adult-onset (18+ years) CVS (P = 0.01), vs 27% of controls. Among subjects with 16519T, 3010A was present in 30% of child-onset vs 0% of adult-onset CVS (P = 0.05) and 2% of controls. The conclusions drawn were: (i) unlike pediatric CVS, adult CVS is not associated with the 16519T and 3010A mtDNA polymorphisms, suggesting a degree of genetic distinction and (ii) similar to the pediatric setting, adult CVS is associated with a substantial burden of co-morbid functional disorders.