Wolbachia infections in natural Anopheles populations affect egg laying and negatively correlate with Plasmodium development.
Wolbachia infections in natural Anopheles populations affect egg laying and negatively correlate with Plasmodium development.
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DOI：
10.1038/ncomms11772
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发表时间：
2016-05-31
影响因子：
16.6
通讯作者：
Catteruccia F
中科院分区：
文献类型：
--
作者：
Shaw WR;Marcenac P;Childs LM;Buckee CO;Baldini F;Sawadogo SP;Dabiré RK;Diabaté A;Catteruccia F
母系遗传的α-变形菌沃尔巴克氏体已被提议作为阻止登革热和疟疾等毁灭性蚊媒传染病传播的工具。在这里，我们研究了最近发现的沃尔巴克氏菌菌株诱导的繁殖操作，该菌株稳定地感染布基纳法索主要疟疾病媒按蚊的天然蚊子种群。我们确定这些感染显着加速产卵，但不会引起细胞质不相容或性别比例扭曲，这两种寄生繁殖表型促进其他沃尔巴克氏体菌株在昆虫宿主内传播。对从房屋收集的 221 只吸血 A. coluzzii 雌性的分析表明，疟原虫寄生虫的存在与沃尔巴克氏体感染之间存在负相关。结合这些结果的数学模型预测，这些内共生体的感染可能会降低人群中疟疾的患病率。这些数据表明沃尔巴克氏体可能是撒哈拉以南非洲疟疾传播动态的重要参与者。 沃尔巴克氏体细菌感染昆虫，有可能用于控制传播疟疾的蚊子种群。在这里，作者提供的证据表明，自然沃尔巴克氏体感染会影响产卵率，并与按蚊体内疟疾寄生虫的减少有关。
The maternally inherited alpha-proteobacterium Wolbachia has been proposed as a tool to block transmission of devastating mosquito-borne infectious diseases like dengue and malaria. Here we study the reproductive manipulations induced by a recently identified Wolbachia strain that stably infects natural mosquito populations of a major malaria vector, Anopheles coluzzii, in Burkina Faso. We determine that these infections significantly accelerate egg laying but do not induce cytoplasmic incompatibility or sex-ratio distortion, two parasitic reproductive phenotypes that facilitate the spread of other Wolbachia strains within insect hosts. Analysis of 221 blood-fed A. coluzzii females collected from houses shows a negative correlation between the presence of Plasmodium parasites and Wolbachia infection. A mathematical model incorporating these results predicts that infection with these endosymbionts may reduce malaria prevalence in human populations. These data suggest that Wolbachia may be an important player in malaria transmission dynamics in Sub-Saharan Africa. Wolbachia bacteria infect insects and could potentially be used to control populations of malaria-transmitting mosquitoes. Here, the authors provide evidence that natural Wolbachia infections affect the rate of egg laying and are associated with reduced presence of malaria parasites in Anopheles mosquitoes.