Descriptive Epidemiology of Adenocarcinomas of the Cardia and Distal Stomach in the Swiss Canton of Vaud
Descriptive Epidemiology of Adenocarcinomas of the Cardia and Distal Stomach in the Swiss Canton of Vaud
复制标题
瑞士沃州贲门和远端胃腺癌的描述性流行病学
DOI：
10.1177/030089169007600203
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发表时间：
1990
期刊：
影响因子：
1.9
通讯作者：
V. Te
中科院分区：
文献类型：
--
作者：
F. Levi;C. la Vecchia;V. Te
从1976- 1987年期间瑞士沃州以人口为基础的癌症登记处提取了胃癌各种解剖学亚部位的发病率登记和生存数据。所有胃腺癌的总体年龄标准化（1980年沃州人口）发病率为男性22.2/100，000，女性8.3/100，000，性别比为2.7。贲门（5.9 vs 0.9，性别比= 6.5）的男性优势明显大于远端胃（10.2 vs 5.0，性别比= 2.0）。来源不明的腺癌的性别比例居中（2.6）。所有胃腺癌的性别比在30岁和40岁时（1.3）低于老年人。在诊断的日历期间，没有观察到明显的趋势随着时间的推移，贲门腺癌，只有一些适度的下降，观察远端胃，在稳定的性别比例的存在。观察到“其他和未指明”子网站的显著下降。因此，在所考虑的日历期间，胃腺癌发病率总体下降，男性约为20%，女性约为30%。发生在远端胃癌的5年生存率（30%）显著高于贲门癌（11%），而“其他和未指明部位”的5年生存率（19%）居中。这些结果表明，贲门腺癌和远端胃腺癌在描述性流行病学和预后方面具有相当大的异质性。这可能有相关的病因学相关性，特别是因为贲门癌似乎与食管癌共享重要的流行病学特征。
Incidence registration and survival data from various anatomical subsites of gastric cancer have been abstracted from the population-based Cancer Registry of the Swiss Canton of Vaud for the period 1976-87. Overall age-standardized (Vaud population in 1980) incidence rates for all gastric adenocarcinomas were 22.2/100,000 males and 8.3/100,000 females, with a sex ratio of 2.7. The male preponderance was appreciably greater for cardia (5.9 vs 0.9, sex ratio = 6.5) than for distal stomach (10.2 vs 5.0, sex ratio = 2.0). Adenocarcinomas of unspecified origin had an intermediate sex ratio (2.6). The sex ratio for all gastric adenocarcinomas was lower in the third and fourth decades of age (1.3) than at older ages. In relation to calendar period of diagnosis, no appreciable trend with time was observed for adenocarcinomas of the cardia, and only some modest decline was observed for distal stomach, in the presence of stable sex ratios. A marked fall was observed for « other and unspecified » subsites. Thus, the overall decline in the incidence of gastric adenocarcinomas over the calendar period considered was about 20% for males and 30% for females. Five-year survival was significantly higher for cancers arising in the distal stomach (30%) than for cardiac carcinomas (11%), and intermediate for « other and unspecified sites » (19%). These results indicate that adenocarcinomas arising from the cardia and those arising from the distal stomach are considerably heterogeneous in relation to descriptive epidemiology and prognosis. This may have relevant etiological correlates, particularly since carcinoma of the cardia appears to share important epidemiologic features with esophageal cancer.