The gene that encodes the phosphatidylinositol-3 kinase regulatory subunit (p85 alpha) maps to chromosome 13 in the mouse.
The gene that encodes the phosphatidylinositol-3 kinase regulatory subunit (p85 alpha) maps to chromosome 13 in the mouse.
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编码磷脂酰肌醇 3 激酶调节亚基 (p85 α) 的基因定位在小鼠的 13 号染色体上。
DOI：
10.1006/geno.1994.1638
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发表时间：
1994
期刊：
影响因子：
4.4
通讯作者：
E. Fisher
中科院分区：
文献类型：
--
作者：
J. Hoyle;I. Yulug;S. Egan;E. Fisher
磷脂酰肌醇3 '激酶是使磷脂酰肌醇、磷脂酰肌醇4-磷酸和磷脂酰肌醇4，5-二磷酸的肌醇环在3'位进行双磷酸化的脂质激酶。这些反应的产物，特别是3，4，5-三磷酸磷脂酰肌醇，被认为是生长信号传导途径中的第二信使，因为激酶的活性在用各种生长因子处理细胞时非常迅速地被激活（9）。
Phosphatidylinositol 3'kinase is a lipid kinase that phos-phorylates the inositol ring of phosphatidylinositol, phospha-tidylinositol 4-phosphate, and phosphatidylinositol 4, 5-bis-phosphate at the 3'position. The products of these reactions, partiçularly phosphatidylinositol 3, 4, 5-trisphosphate, are thought to act as second messengers in growth signaling pathways since the activity of the kinase is very rapidly acti-vated in response to treatment of cells with a wide variety of growth factors (9), Although there is a correlation between