Extensive Prurigo Nodularis: Characterization and Etiology
Extensive Prurigo Nodularis: Characterization and Etiology
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DOI：
10.1159/000358250
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发表时间：
2014-01-01
期刊：
影响因子：
3.4
通讯作者：
Tey, Hong Liang
中科院分区：
文献类型：
--
作者：
Tan, Wei Sheng;Tey, Hong Liang
背景/目标：结节性痒疹（PN）有多种报告的疾病相关性，本研究分析了亚洲队列的人口统计学、临床分布和潜在病因。方法：对在专门的瘙痒门诊就诊的具有广泛病变的PN患者进行了1年的回顾性研究。结果：纳入37例患者（46%为男性，中位年龄53岁）。在所有患者中，可以确定与瘙痒相关的潜在病因。49%（n = 18）的患者有单一病因，而51%（n = 19）有多种病因。在所有患者中，皮肤病是最常见的原因（82%），其中内源性湿疹占大多数（54%），其次是全身性疾病（38%）。结论：在本研究中，所有患有广泛PN的患者都有与瘙痒相关的可识别因素，并且皮肤病是单因素和多因素疾病患者的主要病因。大量患者有潜在的全身性原因。(C)2014 S. Karger AG，巴塞尔
Background/Aims: Prurigo nodularis (PN) has multiple reported disease associations, and this study analyzes the demographics, clinical distribution and underlying etiologies in an Asian cohort. Methods: A 1-year retrospective study was carried out on PN patients with extensive lesions WO) who attended a specialized itch clinic. Results: 37 patients (46% male, median age 53 years) were included. In all patients, an underlying etiologic factor associated with pruritus could be identified. 49% (n = 18) of patients had a single attributable etiology, whilst 51% (n = 19) had multiple etiologies. Among all patients, dermatological disease was the most common cause (82%), of which endogenous eczema comprised the majority of cases (54%), followed by systemic disease (38%). Conclusions: All patients with extensive PN had identifiable factors associated with pruritus in this study, and a dermatological condition was the predominant etiology in both patients with mono- and multifactorial disease. A significant number of patients had underlying systemic causes. (C) 2014 S. Karger AG, Basel