Asymmetric synthesis of ring functionalized trans-2,6-disubstituted piperidines from N-sulfinyl δ-amino β-keto phosphonates.: Total synthesis of (-)-myrtine
Asymmetric synthesis of ring functionalized trans-2,6-disubstituted piperidines from N-sulfinyl δ-amino β-keto phosphonates.: Total synthesis of (-)-myrtine
复制标题
DOI：
10.1021/jo062365t
复制
发表时间：
2007-03-16
影响因子：
3.6
通讯作者：
Zhang, Junyi
中科院分区：
文献类型：
--
作者：
Davis, Franklin A.;Xu, He;Zhang, Junyi
亚亚胺衍生的n -亚亚胺基-氨基β -酮膦酸盐通过胺胺酮转化为磷基二氢吡啶酮，在有机乙酸盐加成和去磷酸化作用下选择性地生成反式-2,6-二取代1,2,5,6-四氢吡啶。
Sulfinimine-derived N-sulfinyl delta-amino beta-ketophosphonates are transformed via the enaminones to the phosphoryl dihydropyridones that selectively give trans-2,6-disubstituted 1,2,5,6-tetrahydropyridines on organocuprate addition and dephosphorylation.