A comparison of long-term survivors and short-term survivors with glioblastoma, subventricular zone involvement: a predictive factor for survival?
A comparison of long-term survivors and short-term survivors with glioblastoma, subventricular zone involvement: a predictive factor for survival?
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DOI：
10.1186/1748-717x-9-95
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发表时间：
2014-04-23
期刊：
影响因子：
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通讯作者：
Combs SE
中科院分区：
文献类型：
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作者：
Adeberg S;Bostel T;König L;Welzel T;Debus J;Combs SE
胶质母细胞瘤（GBM）患者的长期生存率很低。我们着手确定肿瘤位于脑室下区（SZV）的预后良好和预后不良患者的预后因素。我们回顾了50例胶质母细胞瘤LTS长期生存者（LTS）（> 3年）和50例短期生存者（STS）（< 1年）的临床记录、术前和术后MRI成像。这些组的临床特征与生存期延长或缩短一致。所有患者均接受了初次手术或活检以确认GBM诊断，随后进行了放射或化学放射治疗。LTS的中位无进展生存期PFS为25，4个月（2、3-97、8个月），总生存期（OS）为55、9个月（38，2-98，6个月），相比之下，STS的PFS显著较低，为4，2个月（1，4-10，2个月）和OS为6，6个月（2，2-11，6个月）（均p <0.001）。生存分析显示，年龄小于60岁（p <0.001）、肿瘤全切除状态（p <0.001）和肿瘤局部无SVZ接触（p = 0.05）是延长生存期的重要因素。我们的研究结果强调，GBM患者的生存率是异质性的，受多种因素影响。这项研究证实，肿瘤的SVZ位置与生存率显著相关。
Long-term survival is rare in patients with glioblastoma (GBM). We set out to determine prognostic factors for patients with favorable and poor prognosis in regard of tumor localization to the subventricular zone (SZV). We reviewed the clinical records, pre-operative and post-operative MRI imaging of 50 LTS long-term survivors (LTS) (> 3 years) and 50 short-term survivors (STS) (< 1 year) with glioblastoma. These groups were matched for clinical characteristics being consistently associated with prolonged or shortened survival. All patients had undergone initial surgery or biopsy to confirm GBM diagnosis followed by radio- or chemoradiotherapy. LTS had a median progression-free survival PFS of 25, 4 months (2, 3–97, 8 months) and overall-survival (OS) of 55, 9 months (38, 2-98, 6 months) compared to STS who had a significantly lower PFS of 4, 2 months (1, 4–10, 2 months) and OS of 6, 6 months (2, 2–11, 6 months) (each p < 0,001). Survival analysis showed that age under 60 years (p < 0,001), total resection status (p < 0,001) and tumor localization without SVZ contact (p = 0,05) were significant factors for prolonged survival. Our findings underline that survival in GBM patients is heterogeneous and influenced by multiple factors. This study confirms that tumor location with regard to the SVZ is significantly associated with survival.