Accessory Gene Regulator (agr) Dysfunction in Staphylococcus aureus Bloodstream Isolates from South Korean Patients
Accessory Gene Regulator (agr) Dysfunction in Staphylococcus aureus Bloodstream Isolates from South Korean Patients
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DOI：
10.1128/aac.01260-12
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发表时间：
2013-03-01
影响因子：
4.9
通讯作者：
Kim, Yang Soo
中科院分区：
文献类型：
--
作者：
Chong, Yong Pil;Kim, Eun Sil;Kim, Yang Soo
我们描述了来自韩国一家三级医院的具有 agr 功能障碍的耐甲氧西林金黄色葡萄球菌 (MRSA) 血流分离株的遗传和微生物学特征。其中，ST5-SCCmec II 型 agr II 组 MRSA 分离株最为丰富，因为特定的 agr 缺陷谱系可以克隆传播，这种分离株在韩国医院获得性感染中普遍存在。这一发现表明，agr 功能的丧失可能会在医院环境中带来潜在的优势。无论社区或医院是否获得感染，在社区相关 MRSA 或甲氧西林敏感金黄色葡萄球菌克隆中均未观察到特定缺陷 agr 菌株的克隆传播。 agr 缺陷克隆（包括 ST5 和 ST239 MRSA）富含异质耐药万古霉素中型金黄色葡萄球菌。
We describe the genetic and microbiological characteristics of methicillin-resistant Staphylococcus aureus (MRSA) bloodstream isolates with agr dysfunction from a tertiary-care hospital in Korea. Of these, ST5-SCCmec type II-agr group II MRSA isolates, which are known to be prevalent in hospital-acquired infections in Korea, were the most abundant, because of the clonal spread of a specific agr-defective lineage. This finding suggests that the loss of agr function may confer a potential advantage in a hospital setting. Clonal spread of a specific defective-agr strain was not observed among community-associated MRSA or methicillin-susceptible S. aureus clones, regardless of community or hospital acquisition of infection. agr-defective clones, including ST5 and ST239 MRSA, were enriched for heteroresistant vancomycin-intermediate S. aureus.