Biochemical sensing in graphene-enhanced microfiber resonators with individual molecule sensitivity and selectivity
Biochemical sensing in graphene-enhanced microfiber resonators with individual molecule sensitivity and selectivity
复制标题
具有单个分子灵敏度和选择性的石墨烯增强微纤维谐振器中的生化传感
DOI：
10.1038/s41377-019-0213-3
复制
发表时间：
2019-11-22
影响因子：
19.4
通讯作者：
Rao, Yunjiang
中科院分区：
文献类型：
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作者：
Cao, Zhongxu;Yao, Baicheng;Rao, Yunjiang
能够检测和跟踪生物化学分子的光子传感器为从环境分析到医疗诊断的应用中的信息获取提供了强大的工具。生化传感的最终目标是实现定量灵敏度和选择性。石墨烯及其衍生材料作为具有显著光电可调谐性的原子级厚膜，已显示出作为用于传感的化学可调谐平台的独特潜力，从而实现显著的性能增强、多功能化和灵活的器件集成。在这里，我们展示了一个部分还原的氧化石墨烯（prGO）内涂层和光纤校准的法布里-珀罗染料谐振器的生化检测。prGO膜中的多功能化使得腔内荧光共振能量转移（FRET）在可见波段具有化学选择性。此外，通过测量模间干扰，通过噪声消除拍音和锁定外差检测与Hz级精度，我们实现了多巴胺，尼古丁和单链DNA检测的单个分子的灵敏度。这项工作结合了原子层纳米科学和高分辨率光电子学，为高性能生化传感器和系统提供了一种方法。
Photonic sensors that are able to detect and track biochemical molecules offer powerful tools for information acquisition in applications ranging from environmental analysis to medical diagnosis. The ultimate aim of biochemical sensing is to achieve both quantitative sensitivity and selectivity. As atomically thick films with remarkable optoelectronic tunability, graphene and its derived materials have shown unique potential as a chemically tunable platform for sensing, thus enabling significant performance enhancement, versatile functionalization and flexible device integration. Here, we demonstrate a partially reduced graphene oxide (prGO) inner-coated and fiber-calibrated Fabry-Perot dye resonator for biochemical detection. Versatile functionalization in the prGO film enables the intracavity fluorescent resonance energy transfer (FRET) to be chemically selective in the visible band. Moreover, by measuring the intermode interference via noise canceled beat notes and locked-in heterodyne detection with Hz-level precision, we achieved individual molecule sensitivity for dopamine, nicotine and single-strand DNA detection. This work combines atomic-layer nanoscience and high-resolution optoelectronics, providing a way toward high-performance biochemical sensors and systems.