EFFECTS OF CAPSAICIN APPLIED LOCALLY TO ADULT PERIPHERAL-NERVE .2. ANATOMY AND ENZYME AND PEPTIDE CHEMISTRY OF PERIPHERAL-NERVE AND SPINAL-CORD
EFFECTS OF CAPSAICIN APPLIED LOCALLY TO ADULT PERIPHERAL-NERVE .2. ANATOMY AND ENZYME AND PEPTIDE CHEMISTRY OF PERIPHERAL-NERVE AND SPINAL-CORD
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DOI：
10.1016/0304-3959(81)90637-0
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发表时间：
1981-01-01
期刊：
影响因子：
7.4
通讯作者：
POLAK, JM
中科院分区：
文献类型：
--
作者：
AINSWORTH, A;HALL, P;POLAK, JM
辣椒素溶液施加在成年大鼠中大腿坐骨神经的1cm长度周围15分钟。14天后，对治疗区域的神经进行EM检查，没有发现可归因于辣椒素的有髓或无髓纤维变性的迹象。抗氟酸性磷酸酶（FRAP）消失，从中央终端的治疗神经7天。辣椒素（1.5 mM）足以完全降低脊髓中的FRAP。肽P物质和胆囊收缩素（CCK）显着耗尽在该地区的脊髓终端的治疗神经在14天。P物质和CCK不受影响的脊髓区域以外的无髓传入终末区。类似地，传入纤维中不存在的神经降压素和神经垂体后叶素不受坐骨神经的辣椒素处理的影响。局部外周辣椒素引起脊髓精细传入神经末梢的化学变化。
Capsaicin solution was applied for 15 min around a 1-cm length of sciatic nerve in the mid upper leg of adult rats. EM examination of the nerve in the treated region after 14 days shows no signs of degeneration of either myelinated or unmyelinated fibers attributable to the capsaicin. Fluoride-resistant acid phosphatase (FRAP) disappears from the central terminals of the treated nerve by 7 days. Capsaicin (1.5 mM) is sufficient to produce a complete reduction of FRAP in the spinal cord. The peptides substance P and cholecystokinin (CCK) are markedly depleted in the region of spinal cord terminations of the treated nerve at 14 days. Substance P and CCK are not affected in spinal cord regions other than in the unmyelinated afferent terminal zone. Similarly neurotensin and neurophysin which are not present in afferent fibers are not influenced by capsaicin treatment of the sciatic. Chemical changes in the spinal cord terminals of fine afferents follow local peripheral capsaicin.