EVIDENCE FOR NOSOCOMIAL TRANSMISSION OF CANDIDA-ALBICANS OBTAINED BY CA3 FINGERPRINTING
EVIDENCE FOR NOSOCOMIAL TRANSMISSION OF CANDIDA-ALBICANS OBTAINED BY CA3 FINGERPRINTING
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DOI：
10.1128/jcm.33.5.1223-1230.1995
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发表时间：
1995-05-01
影响因子：
9.4
通讯作者：
MCKINNEY, W
中科院分区：
文献类型：
--
作者：
SCHMID, J;TAY, YP;MCKINNEY, W
中度重复序列Ca 3用于对来自新西兰惠灵顿社区的32名住院超过3天的患者、17名最近入院或门诊患者和8名最近再次入院的患者的白色念珠菌分离株和10名口腔分离株，加上来自21名住院患者、26名门诊患者或最近入院的患者、4名最近再次入院的患者的分离株进行指纹分析，和10个健康个体在新西兰奥克兰的社区。在惠灵顿，来自在惠灵顿医院住院超过3天的患者的分离株的遗传多样性显著低于来自门诊患者或最近入院的分离株或来自社区健康个体的分离株，此外，从住院患者中分离出的两个遗传相似菌株簇的频率显著高于其他个体，这些观察结果为医院特异性C菌的院内传播提供了证据（尽管是间接的）。与此相反，没有迹象表明医院特异性传播的C。由于这些结果是在两家医院都没有发生念珠菌病爆发的情况下获得的，因此它们也表明Ca 3指纹图谱可能是预防性医院感染控制程序中的有用工具，可以评估念珠菌的程度。白色念珠菌在医院传播。
The moderately repetitive sequence Ca3 was used to fingerprint Candida albicans isolates from 32 patients hospitalized for more than 3 days, 17 recent admissions or outpatients, and 8 recently readmitted patients and 10 commensal isolates from the community in Wellington, New Zealand, plus isolates from 21 hospitalized patients, 26 outpatients or recent admissions, 4 recently readmitted patients, and 10 healthy individuals in the community in Auckland, New Zealand. In Wellington, isolates from patients hospitalized in Wellington Hospital for more than 3 days were genetically significantly less diverse than were isolates from outpatients or recent admissions or isolates from healthy individuals in the community, In addition, two clusters of genetically similar strains were isolated from hospitalized patients significantly more often than from other individuals, These observations provide evidence (albeit indirectly) for nosocomial transmission of hospital-specific C. albicans strains, In contrast, no indication of hospital-specific transmission of C. albicans was found in auckland Hospital, Since these results were obtained under conditions in which no candidiasis outbreak occurred in either hospital, they also suggest that Ca3 fingerprinting may be a useful tool in preventive nosocomial infection control programs, allowing assessment of the extent of C. albicans transmission occurring in a hospital.