Magnesium supplement intake and C-reactive protein levels in adults
Magnesium supplement intake and C-reactive protein levels in adults
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DOI：
10.1016/j.nutres.2006.05.001
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发表时间：
2006-05-01
影响因子：
4.5
通讯作者：
Rehman, Shakeib
中科院分区：
文献类型：
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作者：
King, Dana E.;Mainous, Arch G., III;Rehman, Shakeib
先前的研究表明，膳食镁可能是饮食和炎症之间关系的关键组成部分;然而，镁补充剂的摄入作用尚未阐明。本研究的目的是确定服用含镁补充剂50 mg/d或更多的人C反应蛋白（CRP）升高的可能性。我们研究了这个问题的研究样本来自全国健康和营养调查1999-2002年，一个全国代表性的，调查的平民，非制度化人口的美国。在美国成年人中，25.6%的人每天服用至少50毫克的镁补充剂。只有21.9%的未服用镁补充剂的人达到或超过了镁摄入量的推荐每日摄入量（RDA），而服用镁补充剂的成年人为60.2%。在调整后的logistic回归分析中，每日镁摄入量低于RDA的人，无论是否服用镁补充剂，CRP升高的可能性均显著增加40%（P <0.05）。在膳食镁摄入量低于50%RDA的人群中，服用镁补充剂的人CRP升高的可能性降低了22%。镁补充剂摄入量与低膳食镁摄入量的人CRP升高的可能性较低相关。需要进行前瞻性研究来检查镁补充剂是否可以降低CRP水平。(c)2006年爱思唯尔公司All rights reserved.
Previous research has indicated that dietary magnesium may be a key component in the association between diet and inflammation; however, the role of intake from magnesium supplements has not been elucidated. The objective of this study was to determine the likelihood of elevated C-reactive protein (CRP) in people taking magnesium-containing supplements of 50 mg/d or more. We examined this issue in a study sample derived from the National Health and Nutrition Examination Survey 1999-2002, a nationally representative, survey of the civilian, noninstitutionalized population of the United States. Among US adults, 25.6% were taking a magnesium supplement of at least 50 mg daily. Only 21.9% of individuals not taking supplemental magnesium met or exceeded the recommended daily allowances (RDA) for magnesium intake compared with 60.2% of adults who were taking magnesium supplements. In adjusted logistic regression analyses, people whose total daily magnesium intake was below the RDA were significantly 40% more likely to have elevated CRP regardless of whether they were taking magnesium supplements (P < .05). Among people with dietary magnesium intake less than 50% RDA, individuals taking magnesium supplements were 22% less likely to have elevated CRP. Magnesium supplement intake is associated with a lower likelihood of elevated CRP in people with low dietary magnesium intake. Prospective studies are needed to examine whether magnesium supplementation can reduce levels of CRP. (c) 2006 Elsevier Inc. All rights reserved.