Incidence trends for human papillomavirus-related and -unrelated oral squamous cell carcinomas in the United States
Incidence trends for human papillomavirus-related and -unrelated oral squamous cell carcinomas in the United States
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DOI：
10.1200/jco.2007.14.1713
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发表时间：
2008-02-01
影响因子：
45.3
通讯作者：
Gillison, Maura L.
中科院分区：
文献类型：
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作者：
Chaturvedi, Anil K.;Engels, Eric A.;Gillison, Maura L.
目的探讨人类乳头瘤病毒(HPV)对美国口腔鳞状细胞癌(OSCCs)流行病学的影响，我们评估了潜在HPV相关和HPV无关的口腔鳞状细胞癌(OSCC)的患者特征、发病率和存活率的差异。患者和方法使用来自9个监测、流行病学和最终结果项目登记(1973-2004)的数据来按解剖部位将口腔鳞癌分类为潜在HPV相关(n=17,625)或HPV无关(n=28,144)。使用连接点回归和年龄-时期-队列模型来评估发病趋势。结果HPV相关性口腔鳞状细胞癌的确诊年龄较非HPV相关性口腔鳞状细胞癌年轻(确诊时平均年龄分别为61.0岁和63.8岁；P
PurposeTo investigate the impact of human papillomavirus ( HPV) on the epidemiology of oral squamous cell carcinomas ( OSCCs) in the United States, we assessed differences in patient characteristics, incidence, and survival between potentially HPV-related and HPV-unrelated OSCC sites.Patients and MethodsData from nine Surveillance, Epidemiology, and End Results program registries ( 1973 to 2004) were used to classify OSCCs by anatomic site as potentially HPV-related ( n = 17,625) or HPV-unrelated ( n = 28,144). Joinpoint regression and age-period-cohort models were used to assess incidence trends. Life-table analyses were used to compare 2-year overall survival for HPV-related and HPV-unrelated OSCCs.ResultsHPV-related OSCCs were diagnosed at younger ages than HPV-unrelated OSCCs ( mean ages at diagnosis, 61.0 and 63.8 years, respectively; P