Prevalence of musculoskeletal pain and statin use
Prevalence of musculoskeletal pain and statin use
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DOI：
10.1007/s11606-008-0636-7
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发表时间：
2008-08-01
影响因子：
5.7
通讯作者：
Mukamal, Kenneth J.
中科院分区：
文献类型：
--
作者：
Buettner, Catherine;Davis, Roger B.;Mukamal, Kenneth J.
背景：肌肉效应是3-羟基-3-甲基戊二酰辅酶A抑制剂(他汀类)最常见的不良反应。然而，在安慰剂对照试验中，肌肉疼痛的发生率在安慰剂组和积极控制组中通常是相似的。目的：我们试图在具有全国代表性的样本中评估他汀类药物的使用是否与肌肉骨骼疼痛的更高患病率相关。方法：使用1999-2002年国家健康和营养检查调查(NHANES)的数据进行横断面分析。参与者是3580名成年人，他们在家中接受了采访，并在流动检查中心接受了检查。参与者被问及社会人口学特征、健康状况、用药情况和肌肉骨骼疼痛。测量和主要结果：在过去的30天内，他汀类药物在4个不同的解剖区域(颈部/上背部、上肢、下背部和下肢)的任何肌肉骨骼疼痛和肌肉骨骼疼痛的患病率和调整后的优势比(OR)。在他汀类药物使用者(n=402)中，22.0%(95%可信区间18.0~26.7%)的患者报告在过去30天内至少有一个解剖区域出现肌肉骨骼疼痛，而未使用他汀类药物的人群中这一比例为16.7%(95%可信区间15.1~18.4%)。与不服用他汀类药物的患者相比，使用他汀类药物的患者的多变量调整优势比(95%CI；p值)为：肌肉骨骼疼痛1.50(1.07-2.11；p=.01)，下腰痛1.59(1.04-2.44，p=.03)，下肢痛1.50(1.02-2.22，p=.03)。结论：肌肉骨骼疼痛在成年人中很常见，且无关节炎。在这个具有全国代表性的样本中，他汀类药物使用者报告肌肉骨骼疼痛的可能性明显更大。
BACKGROUND: Muscle effects are the most common reported adverse effects of 3-hydroxy-3-methylglutaryl coenzyme A inhibitors (statins). However, in placebo-controlled trials the incidence of muscle pain is most often similar for placebo and active control groups.OBJECTIVE: We sought to evaluate whether statin use was associated with a higher prevalence of musculoskeletal pain in a nationally representative sample.METHODS: Cross-sectional analysis using data from the National Health and Nutrition Examination Survey (NHANES) 1999-2002. Participants were 3,580 adults >= 40 years without arthritis who were interviewed at home and examined in a mobile examination center. Participants were asked about sociodemographic characteristics, health conditions, medication use, and musculoskeletal pain. Height, weight, blood pressure, ankle brachial index, and cholesterol were measured.MEASUREMENTS AND MAIN RESULTS: Prevalence and adjusted odds ratios (OR) of any musculoskeletal pain and musculoskeletal pain in 4 different anatomical regions (neck/upper back, upper extremities, lower back, and lower extremities) by statin use during the last 30 days. Among statin users (n=402), 22.0% (95%CI 18.0-26.7%) reported musculoskeletal pain in at least 1 anatomical region during the last 30 days, compared with 16.7% (95%CI 15.1-18.4%) of those who did not use a statin. Compared to persons who did not use statins, those who used statins had multivariable-adjusted odds ratios (95%CI; p value) of 1.50 (1.07-2.11; p=.01) for any musculoskeletal pain, 1.59 (1.04-2.44, p=.03) for lower back pain, and1.50 (1.02-2.22, p=.03) for lower extremity pain.CONCLUSION: Musculoskeletal pain is common in adults >= N40 years without arthritis. In this nationally representative sample, statin users were significantly more likely to report musculoskeletal pain.