BRAIN ATROPHY IN CHRONIC-ALCOHOLIC PATIENTS - A QUANTITATIVE PATHOLOGICAL-STUDY
BRAIN ATROPHY IN CHRONIC-ALCOHOLIC PATIENTS - A QUANTITATIVE PATHOLOGICAL-STUDY
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DOI：
10.1136/jnnp.48.3.211
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发表时间：
1985-01-01
影响因子：
11
通讯作者：
KRIL, J
中科院分区：
文献类型：
--
作者：
HARPER, C;KRIL, J
尽管大量的神经放射学研究显示脑萎缩或萎缩的发生率很高，但基本上没有关于慢性酒精中毒患者脑萎缩的客观神经病理学数据。因此，测量颅内体积（ICV）和脑体积（BV）的尸检研究25例慢性酒精中毒患者和44名对照。根据公式PICS = .** 计算脑周间隙（PICS）图形 **。脑萎缩患者的PICS将增加，因为ICV在整个生命周期中保持不变。对照组的平均PICS值为8.3%，酗酒组为11.3%，伴有韦尼克脑病（硫胺素缺乏症）的酗酒者为14.7%，伴有相关肝脏疾病的酗酒者为16.2%。慢性酒精中毒患者的脑组织损失具有统计学意义，在营养维生素缺乏或酒精性肝病患者中更为严重。
There are essentially no objective neuropathological data on brain atrophy in chronic alcoholic patients despite numerous neuroradiological studies which show a high incidence of shrinkage or atrophy. Therefore measurements were made of the intracranial volume (ICV) and brain volume (BV) in a necropsy study of 25 chronic alcoholic patients and 44 controls. The pericerebral space (PICS) was calculated according to the formula PICS = .**GRAPHIC**. The PICS will increase in patients with brain atrophy since the ICV remains constant throughout life. The mean PICS value was 8.3% in controls, 11.3% in the alcoholic group, 14.7% in alcoholics with superimposed Wernicke''s encephalopathy (thiamine deficiency) and 16.2% in those alcoholics with associated liver disease. There was a statistically significant loss of brain tissue in chronic alcoholic patients which appeared to be more severe in those with associated nutritional vitamin deficiencies or alcoholic liver disease.