Urinary catecholamine levels in daily life are elevated in women at familial risk of breast cancer
Urinary catecholamine levels in daily life are elevated in women at familial risk of breast cancer
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DOI：
10.1016/s0306-4530(03)00150-1
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发表时间：
2004-08-01
影响因子：
3.7
通讯作者：
Bovbjerg, DH
中科院分区：
文献类型：
--
作者：
James, GD;van Berge-Landry, H;Bovbjerg, DH
最近的实验研究表明，面临乳腺癌家族风险的慢性压力的女性对压力实验室任务有更大的神经内分泌反应。这种增强的应激反应是否也发生在实验室以外的日常生活条件下，尚不清楚。在本研究中，比较了73名一级亲属中有乳腺癌家族史的就业妇女（FH+;年龄= 36.8 +/- 8.7）和81名无乳腺癌家族史的就业妇女（FH-;年龄= 38.1 +/- 9.4）在工作（例如上午11：00-下午3：00）、家中（例如下午6：00-晚上10：00）和陡峭期间（例如下午10：00-上午6：00）的尿肾上腺素和去甲肾上腺素排泄率。交感肾上腺髓质反应的差异，以普通的生活压力（工作）进行了评估，在自然的设置。以家族史组为固定因素，体重指数为协变量，日常微环境（工作、家庭和饮酒）为重复因素，进行重复测量MANCOVA，以评估FH+和FH-组之间的儿茶酚胺排泄率是否存在差异。结果表明，有乳腺癌家族史的妇女在工作时肾上腺素排泄率较高（P < 0.005）。此外，FH+组的女性对工作压力的反应也更强，从陡峭到工作，肾上腺素和去甲肾上腺素的增加百分比更大（p < 0.05）。研究结果还表明，与乳腺癌家族史相关的慢性压力效应受到BMI的调节，因此当女性不肥胖时，其影响更加明显。这些发现支持了这样一种观点，即具有乳腺癌家族风险的女性对实验压力源的神经内分泌反应增强，也发生在女性在日常生活中遇到压力源（工作压力）时。进一步的研究，以探索增加反应性的健康后果的妇女在乳腺癌的家族风险，也许在个人在其他危及生命的疾病的家族风险，似乎是必要的。(C)2003爱思唯尔有限公司。保留所有权利。
Recent experimental research has shown that women facing the chronic stress of being at familial risk of breast cancer have greater neuroendocrine reactivity responses to stressful Laboratory tasks. Whether this enhanced stress response also occurs outside the Laboratory under daily life conditions is unknown. In the present study, urinary epinephrine and norepinephrine excretion rates at work (e.g. 11:00 AM-3:00 PM), home (e.g. 6:00 PM-10:00 PM) and during steep (e.g. 10:00 PM-6:00 AM) were compared between 73 employed women with family histories of breast cancer in first degree relatives (FH+; age = 36.8 +/- 8.7) and 81 without such family histories (FH-; age = 38.1 +/- 9.4). Differences in sympathetic adrenal medullary responses to an ordinary Life stressor (work) were assessed in naturalistic settings. Repeated measures MANCOVA with family history group as a fixed factor, body mass index as a covariate and daily microenvironment (work, home and steep) as a repeating factor were conducted to evaluate whether catecholamine excretion rates differed between FH+ and FH- groups. The results revealed that women with family histories of breast cancer had a higher rate of epinephrine excretion while at work (p < 0.005). In addition, women in the FH+ group were also more reactive to the stress of work, showing a greater percentage of increase in both epinephrine and norepinephrine from steep to work (p < 0.05). The results also indicated that the chronic stress effects associated with a family history of breast cancer were moderated by BMI, such that their impact was more pronounced and apparent when women were not obese. These findings support the idea that the heightened neuroendocrine reactivity to experimental stressors in women at familial risk of breast cancer also occurs when women encounter stressors in ordinary life (work stress). Additional research to explore the health consequences of increased reactivity in women at familial risk of breast cancer, and perhaps in individuals at familial risk of other life-threatening disease, would appear warranted. (C) 2003 Elsevier Ltd. All rights reserved.