The emergency function of the adrenal medulla in pain and the major emotions
The emergency function of the adrenal medulla in pain and the major emotions
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DOI：
10.1152/ajplegacy.1914.33.2.356
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发表时间：
1914-02-01
影响因子：
--
通讯作者：
Cannon, WB
中科院分区：
文献类型：
--
作者：
Cannon, WB
像其他内分泌腺一样，人们通过摘除肾上腺和注射其提取物来研究肾上腺。注射实验表明，肾上腺髓质产生的物质(肾上腺素、肾上腺素、肾上腺素等)。能够产生许多深刻的身体变化。其中最重要的变化是：消化道活动停止；血液循环从腹部大血管显著转移到肺、心脏、四肢和中枢神经系统；心脏活力增强；血液含糖量增加。这些惊人的身体变化可能发生在动物的自然生活中，这一重要问题几乎没有引起人们的注意。值得注意的是，这些效应也是由交感神经通路的神经放电引起的--这种放电是在痛苦和巨大情感的危机中发出的。在过去的三年里，在本实验室进行的一系列调查中，L，我们试图深入了解肾上腺素或肾上腺分泌增加所造成的变化的意义，在本文中，我建议讨论我们结果的意义。
Like other endosecretory glands the adrenals have been studied by removing them and by injecting their extracts. Injection experiments have shown that the substance produced by the adrenal medulla (adrenin, adrenalin, epinephrin, etc.) is capable of producing many profound bodily changes. The most important of these changes are: a cessation of the activities of the alimentary canal; a notable shifting of the circulation from the great vessels of the abdomen to the lungs, heart, limbs and central nervous system; an increased cardiac vigor; and an augmentation of the sugar content of the blood. Little attention has been paid to the important question of the possible value of these striking bodily alterations as they might occur in the natural life of animals. It is significant that these effects are caused also by nervous discharges along sympathetic pathways-the discharges that are sent forth in crises of pain and great emotion. During the past three years, in a series of investigations conducted in this laboratory, l we have attempted to gain insight into the meaning of the changes wrought by adrenalin or increased adrenal secretion, and in this paper I propose to discuss the bearings of our results.