Developmental origin of diencephalic sensory relay nuclei in teleosts
Developmental origin of diencephalic sensory relay nuclei in teleosts
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DOI：
10.1159/000095197
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发表时间：
2007-01-01
影响因子：
1.7
通讯作者：
Ito, Hironobu
中科院分区：
文献类型：
--
作者：
Ishikawa, Yuji;Yamamoto, Naoyuki;Ito, Hironobu
我们建议在这里一个新的解释胚胎起源的细胞间脑感觉中继核硬骨鱼的基础上，我们最近的研究基因表达模式的青（Oryzias latipes）胚胎脑和比较hodological研究。有人提出硬骨鱼类的间脑感觉中继系统在脊椎动物中是独特的。硬骨鱼类中继核团（preglomerular complex，PG）被认为起源于间脑的基板（后结节），而哺乳动物的中继核团则起源于间脑的背板（背侧丘脑）。我们的结果使用原位杂交显示，然而，许多pax6或dlx2阳性细胞迁移横向和腹尾侧从间脑椎板基板在发展过程中。大量的集群迁移的巨噬细胞成为本地化的外套层外侧的后结节神经上皮，PG的主要核出现分化。因此，我们认为大多数神经元（如果不是全部的话）至少有一部分可以被视为迁移的神经元核。发育和hodological数据强烈表明，硬骨鱼PG是同源的哺乳动物背侧丘脑的一部分。间脑感觉中继系统的组织和起源可能已经在版权（c）2007 S中得到保护。Karger AG，巴塞尔。
We propose here a novel interpretation of the embryonic origin of cells of diencephalic sensory relay nuclei in teleosts based on our recent studies of gene expression patterns in the medaka ( Oryzias latipes) embryonic brain and comparative hodological studies. It has been proposed that the diencephalic sensory relay system in teleosts is unique among vertebrates. Teleost relay nuclei, the preglomerular complex ( PG), have been assumed to originate from the basal plate ( the posterior tuberculum) of the diencephalon, whereas relay nuclei in mammals are derived from the alar plate ( dorsal thalamus) of the diencephalon. Our results using in situ hybridization show, however, that many pax6- or dlx2-positive cells migrate laterally and ventrocaudally from the diencephalic alar plate to the basal plate during development. Massive clusters of the migrated alar cells become localized in the mantle layer lateral to the posterior tubercular neuroepithelium, from which main nuclei of the PG appear to differentiate. We therefore consider most if not all neurons in least in part, can be regarded as migrated alar nuclei. Developmental and hodological data strongly suggest that the teleost PG is homologous to a part of the mammalian dorsal thalamus. The organization and origin of the diencephalic sensory relay system might have been conserved across Copyright (c) 2007 S. Karger AG, Basel.