Genetic and environmental influences on developing autonomic control of heart rate.
Genetic and environmental influences on developing autonomic control of heart rate.
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遗传和环境对心率自主控制发展的影响。
DOI：
10.1152/ajpregu.1984.246.4.r578
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Johnson,AK
中科院分区：
文献类型：
--
作者：
Tucker,DC;Bhatnagar,RK;Johnson,AK
心血管调节的个体差异来自遗传程序化发育过程和外在（环境）条件之间的动态相互作用。先前在自发性高血压大鼠（SHR）品系的幼鼠中发现的自主神经功能的改变表明了对自主神经发育的遗传影响。在目前的研究中，早期刺激程序先前显示，以减少行为和内分泌反应的啮齿动物在成年期被证明改变神经控制的心率和区域脑儿茶酚胺水平在断奶前期间。在出生后第一周内，每天处理来自SHR和Wistar-Kyoto（WKY）大鼠窝的幼崽。使用阿替洛尔和硝酸甲酯阿托品进行选择性药理学阻断，以确定16天和28日龄时心率的自主控制。联合阻滞用于估计固有心率。在SHR和WKY中，早期处理与基础心率升高、固有心率升高和交感神经张力降低相关。副交感神经对心率的影响在WKY中通过早期处理而升高，在SHR中通过处理而降低。此外，在两个菌株的早期处理产生的背皮质去甲肾上腺素浓度的增加。这些数据表明，早期环境条件可以与血压升高的遗传易感性相互作用，并可能在组织心血管调节的神经控制中发挥潜在的重要作用。
Individual differences in cardiovascular regulation result from a dynamic interaction between genetically programmed developmental processes and extrinsic (environmental) conditions. The alterations in autonomic functioning previously identified among pups of the spontaneously hypertensive rat (SHR) strain suggest a genetic influence on autonomic development. In the present studies, an early stimulation procedure previously shown to reduce the behavioral and endocrine responsiveness of rodents in adulthood was demonstrated to alter both neural control of heart rate and regional brain catecholamine levels during the preweaning period. Pups from litters of SHR and Wistar-Kyoto (WKY) rats were handled daily during the first postnatal week. Selective pharmacological blockade with atenolol and atropine methylnitrate was used to identify autonomic controls of heart rate at 16 and 28 days of age. Combined blockade was used to estimate intrinsic heart rate. In both SHR and WKY, early handling was associated with elevated basal heart rate, elevated intrinsic heart rate, and decreased sympathetic tone. Parasympathetic influence on heart rate was elevated by early handling in WKY and decreased by handling in SHR. In addition, an increase in dorsal cortical norepinephrine concentration was produced by early handling in both strains. These data suggest that early environmental conditions can interact with the genetic predisposition for elevated blood pressure and may play a potentially important role in organizing the neural controls of cardiovascular regulation.