Tetrahydroquinoline derivatives as CRTH2 antagonists
Tetrahydroquinoline derivatives as CRTH2 antagonists
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DOI：
10.1016/j.bmcl.2009.10.094
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发表时间：
2009-12-15
影响因子：
2.7
通讯作者：
Medina, Julio
中科院分区：
文献类型：
--
作者：
Liu, Jiwen;Wang, Yingcai;Medina, Julio
通过高通量筛选发现了一系列四氢喹啉衍生的CRTH2受体抑制剂。这些化合物的效力和药代动力学性质的优化导致了有效的和口服生物可利用的CRTH2拮抗剂的发现。(C)2009爱思唯尔有限公司版权所有。
A series of tetrahydroquinoline-derived inhibitors of the CRTH2 receptor was discovered by a high throughput screen. Optimization of these compounds for potency and pharmacokinetic properties led to the discovery of potent and orally bioavailable CRTH2 antagonists. (C) 2009 Elsevier Ltd. All rights reserved.