Self-modulation of neocortical pyramidal neurons by endocannabinoids
Self-modulation of neocortical pyramidal neurons by endocannabinoids
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DOI：
10.1038/nn.2430
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发表时间：
2009-12-01
影响因子：
25
通讯作者：
Bacci, Alberto
中科院分区：
文献类型：
--
作者：
Marinelli, Silvia;Pacioni, Simone;Bacci, Alberto
控制锥体神经元的兴奋性对于新皮质的功能至关重要。躯体树突状慢自抑制(SSI)允许抑制性神经元调节自身的活动，但在兴奋性细胞中还没有发现类似机制的存在。我们发现，在啮齿类动物中，内源性大麻素介导了SSI和具有明显树突形态的第2/3层锥体神经元抑制性连接的长期调制，表明皮质环路中的谷氨酸能网络是自我调节的。
Control of pyramidal neuron excitability is vital for the functioning of the neocortex. Somatodendritic slow self-inhibition (SSI) allows inhibitory neurons to regulate their own activity, but the existence of similar mechanisms in excitatory cells has not been shown. We found that in rodents endocannabinoids mediated SSI and long-term modulation of inhibitory connections in layer 2/3 pyramidal neurons with a distinct dendritic morphology, suggesting that a glutamatergic network in cortical circuits is self-regulated.