Non-motor symptoms of Parkinson's disease: the patient's perspective
Non-motor symptoms of Parkinson's disease: the patient's perspective
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DOI：
10.1007/s00702-012-0928-2
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发表时间：
2013-04-01
影响因子：
3.3
通讯作者：
Drutyte, Gerda
中科院分区：
文献类型：
--
作者：
Breen, Kieran C.;Drutyte, Gerda
帕金森氏病(PD)有许多不同的表现形式。虽然运动功能障碍是这些症状的最好特征，但这种疾病的非运动症状(NMS)也可以使人致残。这些都被帕金森氏症患者强调为一个特别重要的问题。2008年，对慈善机构英国帕金森氏症的成员进行了一项全面的邮寄调查。这导致10,101名帕金森氏症患者返回。调查内容包括自填非运动问卷(NMSQuest)和生活质量问卷(PDQ-8)。结果显示，帕金森病患者经历NMS的百分比随着病程的延长而增加。然而，那些有较年轻发病形式的人报告说，NMS的影响更大，特别是在记忆、抑郁和睡眠功能方面。NMS与PDQ-8量表呈负相关。相当多的帕金森病患者报告说，他们在确诊前经历了嗅觉、味觉、夜尿和便秘问题，这些可能有助于作为未来的生物标志物。尽管最近我们对帕金森病相关的NMS的了解有了很大的提高，但人们仍然普遍缺乏对NMS对帕金森病患者的重要性的认识。需要进一步的研究来确定应对这些问题的最佳治疗方法。
Parkinson's disease (PD) can be manifested in many different ways. Although motor dysfunction represents the best characterised of the symptoms, the non-motor symptoms (NMS) of the condition can be equally disabling for people. These have been highlighted as being an issue of particular importance by people with PD. A comprehensive postal survey of members of the charity Parkinson's UK took place in 2008. This resulted in returns from 10,101 people with PD. The self-completed Non-Motor Questionnaire (NMSQuest) and quality of life scale (PDQ-8) were contained within the survey. The results showed that the percentage of people with PD experiencing NMS increased with the duration of the disease. However, people who had the younger onset form of the condition reported a greater impact of NMS, particularly in the areas of memory, depression and sleep function. There is an inverse correlation between NMS and (PDQ-8 scale). A significant number of people with PD reported that they experienced problems with olfaction, taste, nocturia and constipation prior to diagnosis and these may help to serve as a future biomarker for the condition. Although our understanding of PD-associated NMS has increased considerably in the recent past, there is still a general lack of awareness of the importance of NMS for people with PD. Further research is required to identify the best treatments that should be employed to address them.