Stress biomarkers in medical students participating in a mind body medicine skills program.
Stress biomarkers in medical students participating in a mind body medicine skills program.
复制标题
DOI：
10.1093/ecam/neq039
复制
发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Amri H
中科院分区：
文献类型：
--
作者：
Maclaughlin BW;Wang D;Noone AM;Liu N;Harazduk N;Lumpkin M;Haramati A;Saunders P;Dutton M;Amri H
乔治城大学医学院为医学生提供了一门选修的身心医学技能（MBMS）课程，以促进自我护理和自我意识。参与的医学生报告说，他们比非参与者更好地管理了学业压力和幸福感。在这项研究中，我们试图通过测量一年级医学生的生理变化来评估MBMS的减压效果。唾液样本收集之前（1月，时间1（T1）-干预前）和课程完成时（5月，时间2（T2 p）-干预后），以及从非参与医学生（5月，时间2（T2 c）-对照）。T2 p和T2 c的采集与期末考试期间一致。测定皮质醇、硫酸脱氢表雄酮（DHEA-S）、睾酮和分泌型免疫球蛋白A（sIgA）。T2 p时的平均早晨唾液皮质醇为基线T1时平均值的97%，显著低于T2 c（2.4）（95%置信区间（CI）0.57-1.60，P = 0.001）; DHEA-S显示出与皮质醇相似的模式，在早晨和晚上采集时，T2 p水平均显著低于T2 c（P <0.001）。T2 p时的TER（0.85）也低于T2 c（1.6）（95% CI 0.53-1.3，P = 0.01）。sIgA水平无统计学差异。在直接比较中，所有皮质醇、DHEA-S和睾酮值的T2 c和T2 p均值均显著不同。参与者在整个学期内保持他们的荷尔蒙平衡在正常范围内，而对照组显示出显着增加的水平，可能是由于学期末的考试压力而加剧的。据我们所知，这是第一个研究，以评估医学生的MBMS计划的生理效益。
Georgetown University School of Medicine offers an elective Mind-Body Medicine Skills (MBMS) course to medical students to promote self-care and self-awareness. Participating medical students reported better management of academic stress and well-being than non-participants. In this study, we sought to assess the stress-reducing effects of MBMS by measuring physiological changes in first-year medical students. Saliva samples were collected before (January, time 1 (T1)-pre-intervention) and upon completion of the course (May, time 2 (T2p)-post-intervention), as well as from non-participating medical students (May, time 2 (T2c)-control). The T2p and T2c collections coincided with the period of final examinations. Cortisol, dehydroepiandrosterone-sulfate (DHEA-S), testosterone and secretory immunoglobulin A (sIgA) were measured. The mean morning salivary cortisol at T2p was 97% of the mean at baseline T1 which was significantly lower than for T2c (2.4) (95% confidence interval (CI) 0.57–1.60, P = .001); DHEA-S showed similar pattern as cortisol where the T2p levels were significantly lower than T2c (P < .001) in both morning and evening collections. Testosterone ratio at T2p (0.85) was also lower than T2c (1.6) (95% CI 0.53–1.3, P = .01). sIgA levels were not statistically different. On direct comparison, the T2c and T2p means were significantly different for all cortisol, DHEA-S and testosterone values. Participants maintained their hormonal balance within the normal range throughout the academic semester while the control group showed significantly increased levels, probably exacerbated by the end of the semester exam stress. To our knowledge, this is the first study to assess the physiologic benefits of a MBMS program in medical students.
登录
查看更多内容
影响因子：
5.4
作者：
FirthCozens, J;Greenhalgh, J
通讯作者：
Greenhalgh, J
影响因子：
5.6
作者：
Baid, S;Nieman, LK
通讯作者：
Nieman, LK
影响因子：
2.2
作者：
Gordon, James S;Edwards, Denise Murray
通讯作者：
Edwards, Denise Murray
影响因子：
6
作者：
Hojat, M;Mangione, S;Magee, M
通讯作者：
Magee, M
DOI：
10.1073/pnas.0807041106
发表时间：
2009-01-20
影响因子：
11.1
作者：
Liston, C.;McEwen, B. S.;Casey, B. J.
通讯作者：
Casey, B. J.