Neural system for controlling the contents of object working memory in humans
Neural system for controlling the contents of object working memory in humans
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DOI：
10.1093/cercor/bhj096
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发表时间：
2006-11-01
期刊：
影响因子：
3.7
通讯作者：
Courtney, Susan M.
中科院分区：
文献类型：
--
作者：
Roth, Jennifer K.;Serences, John T.;Courtney, Susan M.
工作记忆是对当前相关信息的主动维护，是一种灵活的系统，允许快速而频繁地改变已排练的信息的目标。成功的WM维护可以防止干扰干扰，同时允许新的任务相关信息更新WM的内容。我们使用功能磁共振成像显示，当WM内容被更新时，无论刺激类型(面孔或房屋)，额顶网络显示出一过性的激活增加。这些区域中的一些与转移注意力的研究中发现的高度相似，支持了更新工作记忆涉及给予当前知觉输入的注意优先级的改变的观点。前额叶中腹外侧区，靠近额叶下沟和中央前沟(额叶下部交界处)交界处的区域，以前被认为与认知控制有关，在更新过程中表现出一过性的活动增加以及持续的维持活动。更靠前的前额叶回，额中回，以前被认为在维持过程中保护WM的内容不受干扰刺激，在更新过程中表现出一过性的活动增加。目前的研究表明，WM的更新是对视觉刺激的更多关注和系统干扰保护状态变化的综合结果。
Working memory (WM), the active maintenance of currently relevant information, is a flexible system allowing for fast and frequent goal-directed changes of rehearsed information. Successful WM maintenance prevents interference from distracting stimuli while allowing new task-relevant information to update the contents of WM. We used functional magnetic resonance imaging to show that when WM contents were updated, regardless of stimulus type (faces or houses), a frontoparietal network showed transient increases in activation. Some of these regions are highly similar to those identified in studies of shifting attention, supporting the idea that updating WM involves a change in the attentional priority afforded to the current perceptual input. A region within the mid-ventrolateral prefrontal cortex, near the junction of the inferior frontal sulcus and precentral sulcus (inferior frontal junction), that has previously been implicated in cognitive control, demonstrated transient increases in activity during updating as well as sustained maintenance activity. A more anterior prefrontal region, middle frontal gyrus, previously implicated in protecting the contents of WM from interfering stimuli during maintenance, demonstrated transient increases in activity during updating. The current study suggests that updating WM results from a combination of increased attention to the visual stimulus and a change in the system's interference protection state.