A molecular epidemiological study of rabies in Puerto Rico
A molecular epidemiological study of rabies in Puerto Rico
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DOI：
10.1016/j.virusres.2007.08.002
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发表时间：
2008-01-01
期刊：
影响因子：
5
通讯作者：
Wandeler, Alexander I.
中科院分区：
文献类型：
--
作者：
Nadin-Davis, Susan A.;Velez, Jafet;Wandeler, Alexander I.
猫鼬是波多黎各岛上狂犬病的主要宿主。本报告描述了对 1997 年从该岛发现的代表性狂犬病病毒进行的分子流行病学研究。确定了在该岛局部地区传播的两种密切相关但不同的变种。这些病毒缺乏单系关系表明狂犬病曾两次独立入侵该岛。这两种波多黎各变异都与一种被称为中北部臭鼬株的变异密切相关，该变异目前在北美臭鼬种群中流行，并且都是殖民时期传播的世界性狂犬病谱系的成员。然而，波多黎各病毒明显不同于目前在古巴猫鼬中传播的病毒，后者在流行病学上与墨西哥狗狂犬病病毒密切相关。这项研究清楚地确定了目前在这两个加勒比岛屿上传播的狂犬病病毒的独特起源。皇冠版权所有 (c) 2007 由 Elsevier B.V 出版。保留所有权利。
The mongoose is the principal reservoir for rabies on the island of Puerto Rico. This report describes a molecular epidemiological study of representative rabies viruses recovered from the island in 1997. Two closely related but distinct variants circulating in regionally localised parts of the island were identified. The lack of a monophyletic relationship of these viruses suggests that two independent incursions of rabies onto the island have occurred. Both of these Puerto Rican variants were closely related to a variant, known as the north central skunk strain, currently circulating in North American skunk populations and all are members of the cosmopolitan rabies lineage spread during the colonial period. However, the Puerto Rican viruses are clearly distinct from those presently circulating in mongooses in Cuba and which are epidemiologically closely linked to the Mexican dog rabies virus. This study clearly establishes the distinct origins of the rabies viruses now circulating on these two Caribbean islands. Crown Copyright (c) 2007 Published by Elsevier B.V. All rights reserved.